Rotenberg V S, Hadjez J, Kimhi R, Indurski P, Sirota P, Mosheva T, Benatov R, Elizur A
Y. Abarbanel Mental Health Center, Bat-Yam, Israel.
Biol Psychiatry. 1997 Aug 15;42(4):267-74. doi: 10.1016/S0006-3223(96)00343-5.
Polysomnography was performed in 20 depressed patients and 8 normal controls for 2 consecutive nights. A subset of patients had 3 consecutive nights. Patients were assigned to groups according to the presence (group I) or absence (group II) of a first night effect (REM sleep latency on the first night in the laboratory was at least 30 min longer than on the second night). The groups were equivalent with regard to gender distribution, age, and severity of depression. In group I, REM sleep latency on nights 2 and 3 was significantly shorter than in group II. REM sleep percentage on the second night in group I was increased compared to the first night. A shift of REM sleep to the first cycle was prominent on the first night only in patients with a first night effect. On average, delta sleep was preserved in group I compared to group II. We suggest that the first night effect reflects a physiological system with greater capacity to respond adaptively and to preserve homeostasis when confronted with environmental stressors.
对20例抑郁症患者和8名正常对照者进行了连续两晚的多导睡眠图监测。部分患者进行了连续三晚的监测。根据是否存在首夜效应（实验室首夜的快速眼动睡眠潜伏期比第二晚至少长30分钟）将患者分为两组（I组）或无首夜效应组（II组）。两组在性别分布、年龄和抑郁严重程度方面相当。I组第2晚和第3晚的快速眼动睡眠潜伏期明显短于II组。I组第二晚的快速眼动睡眠百分比与第一晚相比有所增加。只有存在首夜效应的患者在首夜快速眼动睡眠向第一个周期的转移才较为明显。平均而言，与II组相比，I组的慢波睡眠得以保留。我们认为，首夜效应反映了一种生理系统，该系统在面对环境应激源时具有更强的适应性反应和维持内环境稳定的能力。
