肌动蛋白成核作用：Spire——独树一帜的肌动蛋白成核因子。
Actin nucleation: spire - actin nucleator in a class of its own.
作者信息
Baum Buzz, Kunda Patricia
机构信息
Ludwig Institute for Cancer Research, UCL Branch, London, UK.
出版信息
Curr Biol. 2005 Apr 26;15(8):R305-8. doi: 10.1016/j.cub.2005.04.004.
PMID:15854898
Abstract
The rate limiting step for actin filament polymerisation is nucleation, and two types of nucleator have been described: the Arp2/3 complex and the formins. A recent study has now identified in Spire a third class of actin nucleator. The four short WH2 repeats within Spire bind four consecutive actin monomers to form a novel single strand nucleus for 'barbed end' actin filament elongation.
摘要
肌动蛋白丝聚合的限速步骤是成核作用，并且已经描述了两种类型的成核剂：Arp2/3复合物和formin。最近的一项研究现已在Spire中鉴定出第三类肌动蛋白成核剂。Spire内的四个短WH2重复序列结合四个连续的肌动蛋白单体，形成一个用于“刺端”肌动蛋白丝伸长的新型单链核。
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