Langley Joanne M
Clinical Trials Research Centre, the IWK Health Centre and Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada.
Pediatr Crit Care Med. 2005 May;6(3 Suppl):S25-9. doi: 10.1097/01.PCC.0000161934.79270.66.
To define urinary tract infections in critically ill children in the intensive care unit setting for the purpose of surveillance of infection, enrollment of children in sepsis trials, and for trials of therapy and prevention.
Summary of the literature with review and consensus by experts in the field.
A variety of definitions, only some of which have been validated for use in children, were identified. The Centers for Disease Control criteria for the definition of nosocomial infection have been used to establish surveillance data for inter-institutional comparison. Validated definitions for the febrile child were identified. Using the known characteristics of symptoms, signs, and laboratory criteria for urinary tract infections, definitions for definite, possible, and probable urinary tract infection were derived.
Definitions for definite, probable, and possible urinary tract infection were achieved by consensus that can be used for surveillance and enrolment in sepsis trials. Future research should determine the utility of these definitions in the critically ill child and adapt them accordingly.
为了监测感染情况、将儿童纳入脓毒症试验以及进行治疗和预防试验，明确重症监护病房中危重症儿童的尿路感染情况。
对该领域专家的文献进行综述并达成共识。
确定了多种定义，其中只有部分在儿童中得到验证。疾病控制中心关于医院感染定义的标准已用于建立机构间比较的监测数据。确定了发热儿童的有效定义。利用已知的尿路感染症状、体征和实验室标准特征，得出了确诊、可能和疑似尿路感染的定义。
通过共识达成了确诊、疑似和可能尿路感染的定义，可用于脓毒症试验的监测和入组。未来的研究应确定这些定义在危重症儿童中的实用性，并据此进行调整。
