Sherkatolabbasieh H, Firouzi M, Shafizadeh S, Nekohid M
Department of Pediatrics, Faculty of Medicine, Iran.
Internal Medicine Department, Faculty of Medicine, Iran.
New Microbes New Infect. 2020 Jul 7;37:100728. doi: 10.1016/j.nmni.2020.100728. eCollection 2020 Sep.
Urinary tract infection (UTI) is associated with increased health burden among paediatric patients. Vitamin D is known for its immunoregulatory effects, particularly antimicrobial activity. The aim of this study was to determine the relationship between vitamin D levels and UTIs in children referred to a hospital in Khorramabad, Iran. This case-control study was conducted on 258 children aged between 2 and 14 years; 44 children with UTI and 214 healthy children were enrolled. Patients were tested for UTI on the basis of signs and symptoms, and urine culture and analysis. Vitamin D levels were measured in children in both groups. According to the results, the two groups were significantly different in terms of sex (p 0.007). There was no significant difference between the mean vitamin D among the two groups. Vitamin D levels were not related to UTI by multivariate logistic regression. The relationship between the level of vitamin D and the incidence of UTI in children in accordance with age and sex had an odds ratio of 0.99, indicating that for a 1-unit increase in vitamin D, the odds of having a UTI decreased by 1, a correlation which was not statistically significant. According to the findings of this study, no significant correlation was found between UTI and vitamin D levels. However, the prevalence of UTI was higher in girls than boys.
尿路感染（UTI）与儿科患者健康负担增加相关。维生素D因其免疫调节作用而闻名，尤其是抗菌活性。本研究的目的是确定伊朗霍拉马巴德一家医院收治的儿童维生素D水平与UTI之间的关系。这项病例对照研究对258名2至14岁的儿童进行；纳入了44名UTI患儿和214名健康儿童。根据体征和症状以及尿培养和分析对患者进行UTI检测。测量了两组儿童的维生素D水平。结果显示，两组在性别方面存在显著差异（p = 0.007）。两组的平均维生素D水平之间无显著差异。多因素逻辑回归分析显示维生素D水平与UTI无关。根据年龄和性别，维生素D水平与儿童UTI发病率之间的比值比为0.99，这表明维生素D每增加1个单位，患UTI的几率降低1，但这种相关性无统计学意义。根据本研究结果，未发现UTI与维生素D水平之间存在显著相关性。然而，UTI的患病率在女孩中高于男孩。
