高危血清阴性男性中低水平的1型人类免疫缺陷病毒DNA
Low levels of human immunodeficiency virus type 1 DNA in high-risk seronegative men.
作者信息
Koning Fransje A, van der Vorst Teun J K, Schuitemaker Hanneke
机构信息
Sanquin Research at CLB, Dept. of Clinical Viro Immunology, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands.
出版信息
J Virol. 2005 May;79(10):6551-3. doi: 10.1128/JVI.79.10.6551-6553.2005.
Abstract
We detected human immunodeficiency virus type 1 (HIV-1) DNA at very low levels in sequential peripheral blood mononuclear cell samples of five out of six high-risk, seronegative, homosexual men and five out of five individuals 7.8 to 1.6 years prior to seroconversion. These data indicate a high prevalence of low-level HIV-1 DNA in exposed seronegative individuals.
摘要
在6名高危、血清学阴性的同性恋男性中的5名以及血清阳转前7.8至1.6年的5名个体的连续外周血单核细胞样本中，我们检测到了极低水平的1型人类免疫缺陷病毒（HIV-1）DNA。这些数据表明，在暴露的血清学阴性个体中，低水平HIV-1 DNA的患病率很高。
相似文献
1
Low levels of human immunodeficiency virus type 1 DNA in high-risk seronegative men.
J Virol. 2005 May;79(10):6551-3. doi: 10.1128/JVI.79.10.6551-6553.2005.
2
Characterization of human immunodeficiency virus (HIV1C) variants in peripheral blood mononuclear cells and spermatozoa.
J Med Virol. 2011 May;83(5):760-7. doi: 10.1002/jmv.22041.
3
Longitudinal quantification of human immunodeficiency virus type 1 DNA and RNA in long-term nonprogressors.
J Infect Dis. 1999 Jun;179(6):1542-8. doi: 10.1086/314757.
4
Human Immunodeficiency Virus type 1 in seronegative infants born to HIV-1-infected mothers.
Virol J. 2006 Jun 29;3:52. doi: 10.1186/1743-422X-3-52.
5
Development of methods for coordinate measurement of total cell-associated and integrated human immunodeficiency virus type 1 (HIV-1) DNA forms in routine clinical samples: levels are not associated with clinical parameters, but low levels of integrated HIV-1 DNA may be prognostic for continued successful therapy.
J Clin Microbiol. 2007 Apr;45(4):1288-97. doi: 10.1128/JCM.01926-06. Epub 2007 Feb 21.
6
Human immunodeficiency virus type 1 infection in homosexual men who remain seronegative for prolonged periods.
N Engl J Med. 1989 Jun 1;320(22):1458-62. doi: 10.1056/NEJM198906013202205.
7
8
Viral and immunologic examination of human immunodeficiency virus type 1-infected, persistently seronegative persons.
J Infect Dis. 1999 Oct;180(4):1033-42. doi: 10.1086/315024.
9
Detection of low copy numbers of HIV-1 proviral DNA in patient PBMCs by a high-input, sequence-capture PCR (Mega-PCR).
J Med Virol. 2004 Jan;72(1):1-9. doi: 10.1002/jmv.10535.
10
Early levels of HIV-1 DNA in peripheral blood mononuclear cells are predictive of disease progression independently of HIV-1 RNA levels and CD4+ T cell counts.
J Infect Dis. 2005 Jul 1;192(1):46-55. doi: 10.1086/430610. Epub 2005 May 31.
引用本文的文献
1
Recent Insights into the HIV/AIDS Pandemic.
Microb Cell. 2016 Sep 5;3(9):451-475. doi: 10.15698/mic2016.09.529.
2
The Immune Fulcrum: Regulatory T Cells Tip the Balance Between Pro- and Anti-inflammatory Outcomes upon Infection.
Prog Mol Biol Transl Sci. 2015;136:217-43. doi: 10.1016/bs.pmbts.2015.07.015. Epub 2015 Aug 18.
3
Impaired viral entry cannot explain reduced CD4+ T cell susceptibility to HIV type 1 in certain highly exposed individuals.
AIDS Res Hum Retroviruses. 2008 Nov;24(11):1415-27. doi: 10.1089/aid.2007.0256.
4
Serodeconversion of HIV antibody-positive AIDS patients following treatment with V-1 Immunitor.
J Biomed Biotechnol. 2009;2009:934579. doi: 10.1155/2009/934579. Epub 2008 Oct 28.
5
Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapy.
J Virol. 2009 Jan;83(1):329-35. doi: 10.1128/JVI.01763-08. Epub 2008 Oct 22.
6
Human Immunodeficiency Virus type 1 in seronegative infants born to HIV-1-infected mothers.
Virol J. 2006 Jun 29;3:52. doi: 10.1186/1743-422X-3-52.
7
Understanding the "lucky few": the conundrum of HIV-exposed, seronegative individuals.
Curr HIV/AIDS Rep. 2006 Feb;3(1):26-31. doi: 10.1007/s11904-006-0005-2.
本文引用的文献
1
Correlates of resistance to HIV-1 infection in homosexual men with high-risk sexual behaviour.
AIDS. 2004 May 21;18(8):1117-26. doi: 10.1097/00002030-200405210-00005.
2
Persistence of extraordinarily low levels of genetically homogeneous human immunodeficiency virus type 1 in exposed seronegative individuals.
J Virol. 2003 Jun;77(11):6108-16. doi: 10.1128/jvi.77.11.6108-6116.2003.
3
Broad human immunodeficiency virus (HIV)-specific T cell responses to conserved HIV proteins in HIV-seronegative women highly exposed to a single HIV-infected partner.
J Infect Dis. 2003 Apr 1;187(7):1053-63. doi: 10.1086/368127. Epub 2003 Mar 19.
4
Human immunodeficiency virus (HIV)-specific cytotoxic T lymphocyte activity in HIV-exposed seronegative persons.
J Infect Dis. 1999 Mar;179(3):538-47. doi: 10.1086/314621.
5
Occurrence of human immunodeficiency virus type 1 (HIV-1)-specific cytolytic T cell activity in apparently uninfected children born to HIV-1-infected mothers.
J Infect Dis. 1994 Nov;170(5):1296-9. doi: 10.1093/infdis/170.5.1296.
6
HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women.
Nat Med. 1995 Jan;1(1):59-64. doi: 10.1038/nm0195-59.
7
Biological and biochemical characterization of a cloned Leu-3- cell surviving infection with the acquired immune deficiency syndrome retrovirus.
J Exp Med. 1986 Jul 1;164(1):280-90. doi: 10.1084/jem.164.1.280.
8
Human immunodeficiency virus type 1 infection in homosexual men who remain seronegative for prolonged periods.
N Engl J Med. 1989 Jun 1;320(22):1458-62. doi: 10.1056/NEJM198906013202205.
9
The reservoir for HIV-1 in human peripheral blood is a T cell that maintains expression of CD4.
Science. 1989 Jul 21;245(4915):305-8. doi: 10.1126/science.2665081.
10
Rapid and simple method for purification of nucleic acids.
J Clin Microbiol. 1990 Mar;28(3):495-503. doi: 10.1128/jcm.28.3.495-503.1990.
Zotero 插件