Hahn G H, Koch A, Melbye M, Mølbak K
Department of Epidemiology Research, Danish Epidemiology Science Centre, Copenhagen, Denmark.
Acta Paediatr. 2005 Jan;94(1):99-106. doi: 10.1111/j.1651-2227.2005.tb01795.x.
To provide knowledge of drug prescription patterns in general and of antibiotics in particular, and number of consultations and diagnoses leading to prescriptions among children aged 0-4 y in the Arctic.
A population-based cohort of children aged 0-4 y, living in Sisimiut, the second largest town in Greenland, was followed from August 1996 to December 1998. Information on consultations, diagnoses and drug prescriptions was obtained from medical files at the local health centre.
Among 280 participating children, the mean number of consultations per child was 5.64 per year at risk (range 0-17), of prescriptions 4.02 per year at risk (range 0-17.2), and of prescribed systemic antibiotics per child 1.47 per year at risk (range 0-7.25). Systemic antibiotics formed the therapeutic subgroup most often issued for children, constituting 33.5% of all prescriptions. Of the systemic antibiotics, 50% were broad-spectrum penicillins, 34% penicillin V, 14% macrolides and 2% other antibiotics. The most frequent diagnoses leading to drug prescription in general as well as to prescription of systemic antibiotics were respiratory tract infections, accounting for 59% of all prescriptions and 81% of prescriptions of systemic antibiotics. Children aged 1/2-1 y of age had the highest prescription rates of drugs in general and of systemic antibiotics.
Compared to other countries, prescription rates of drugs in general and of systemic antibiotics in particular were high. The use of broad-spectrum penicillins was higher than recommended in Greenlandic national guidelines, and might be reduced.
了解北极地区0至4岁儿童的总体用药处方模式,尤其是抗生素的处方模式,以及导致处方的会诊次数和诊断情况。
对居住在格陵兰第二大城镇西西缪特的0至4岁儿童进行基于人群的队列研究,研究时间为1996年8月至1998年12月。通过当地健康中心的医疗档案获取会诊、诊断和药物处方信息。
在280名参与研究的儿童中,每名儿童每年的平均会诊次数为5.64次(范围为0至17次),每年的处方次数为4.02次(范围为0至17.2次),每名儿童每年使用的全身性抗生素处方次数为1.47次(范围为0至7.25次)。全身性抗生素是最常开具给儿童的治疗亚组,占所有处方的33.5%。在全身性抗生素中,50%为广谱青霉素,34%为青霉素V,14%为大环内酯类抗生素,2%为其他抗生素。总体而言,导致药物处方以及全身性抗生素处方的最常见诊断是呼吸道感染,占所有处方的59%,占全身性抗生素处方的81%。1/2至1岁的儿童总体用药处方率和全身性抗生素处方率最高。
与其他国家相比,总体药物处方率,尤其是全身性抗生素处方率较高。在格陵兰国家指南中,广谱青霉素的使用高于推荐水平,可能需要减少。