血管生成中的成纤维细胞生长因子/成纤维细胞生长因子受体系统

Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis.

作者信息

Presta Marco, Dell'Era Patrizia, Mitola Stefania, Moroni Emanuela, Ronca Roberto, Rusnati Marco

机构信息

Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.

出版信息

Cytokine Growth Factor Rev. 2005 Apr;16(2):159-78. doi: 10.1016/j.cytogfr.2005.01.004. Epub 2005 Feb 2.

DOI:10.1016/j.cytogfr.2005.01.004

PMID:15863032

Abstract

Fibroblast growth factors (FGFs) are a family of heparin-binding growth factors. FGFs exert their pro-angiogenic activity by interacting with various endothelial cell surface receptors, including tyrosine kinase receptors, heparan-sulfate proteoglycans, and integrins. Their activity is modulated by a variety of free and extracellular matrix-associated molecules. Also, the cross-talk among FGFs, vascular endothelial growth factors (VEGFs), and inflammatory cytokines/chemokines may play a role in the modulation of blood vessel growth in different pathological conditions, including cancer. Indeed, several experimental evidences point to a role for FGFs in tumor growth and angiogenesis. This review will focus on the relevance of the FGF/FGF receptor system in adult angiogenesis and its contribution to tumor vascularization.

摘要

成纤维细胞生长因子（FGFs）是一类肝素结合生长因子。FGFs通过与多种内皮细胞表面受体相互作用发挥其促血管生成活性，这些受体包括酪氨酸激酶受体、硫酸乙酰肝素蛋白聚糖和整合素。它们的活性受到多种游离和细胞外基质相关分子的调节。此外，FGFs、血管内皮生长因子（VEGFs）和炎性细胞因子/趋化因子之间的相互作用可能在包括癌症在内的不同病理状态下血管生长的调节中发挥作用。实际上，多项实验证据表明FGFs在肿瘤生长和血管生成中起作用。本综述将聚焦于FGF/FGF受体系统在成人血管生成中的相关性及其对肿瘤血管形成的作用。