Ornitz D M
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Bioessays. 2000 Feb;22(2):108-12. doi: 10.1002/(SICI)1521-1878(200002)22:2<108::AID-BIES2>3.0.CO;2-M.
Fibroblast growth factors (FGFs) comprise a large family of developmental and physiological signaling molecules. All FGFs have a high affinity for the glycosaminoglycan heparin and for cell surface heparan sulfate proteoglycans. A large body of biochemical and cellular evidence points to a direct role for heparin/heparan sulfate in the formation of an active FGF/FGF receptor signaling complex. However, until recently there has been no direct demonstration that heparan is required for the biological activity of FGF in a developmental system in vivo. A recent paper by Lin et al.(1) has broken through this barrier to demonstrate that heparan sulfate is essential for FGF function during Drosophila development. The establishment of a role for heparan sulfate in FGFR activation in vivo suggests that tissue-specific differences in the structure of heparan may modulate the activity of FGF. BioEssays 22:108-112, 2000.
成纤维细胞生长因子（FGFs）构成了一个由发育和生理信号分子组成的大家族。所有FGFs对糖胺聚糖肝素以及细胞表面硫酸乙酰肝素蛋白聚糖都具有高亲和力。大量的生化和细胞证据表明，肝素/硫酸乙酰肝素在活性FGF/FGF受体信号复合物的形成中起直接作用。然而，直到最近，还没有直接证据表明硫酸乙酰肝素在体内发育系统中对FGF的生物学活性是必需的。Lin等人最近发表的一篇论文（1）突破了这一障碍，证明硫酸乙酰肝素在果蝇发育过程中对FGF功能至关重要。体内硫酸乙酰肝素在FGFR激活中的作用的确立表明，硫酸乙酰肝素结构的组织特异性差异可能调节FGF的活性。《生物论文》2000年第22卷：108 - 112页。
