Demir Temir A, Işikli Burhanettin, Urer Selim M, Berber Asiye, Akar Tamer, Canbek Mediha, Kalyoncu Cemalettin
Osmangazi University Art and Science Faculty Department of Chemistry.
Biometals. 2005 Feb;18(1):7-13. doi: 10.1007/s10534-004-1209-9.
The aim of the study was to determine the nickel concentrations of soil and plant specimens taken from a rural area exposed to cement factory emissions and also to determine the blood concentrations and sensitivity conditions observed in humans residing in this rural area. The study was carried out in Cukurhisar, a town in Eskişehir-Turkey, between May 2000 and March 2001. Beside the 108 soil (36 for control) and plant specimens, which were taken from 8 directions from the cement factory, blood samples of the individuals residing in this area were taken from 258 subjects (258 for control) following a physical examination, and patch tests were also applied. The nickel concentrations of the soil and plant specimens taken from different places in different directions of the factory were higher than in the control areas. The physical examination of subjects did not reveal results different from those of the control group except for the diagnosis of contact dermatitis. The analyses of venous blood samples showed that nickel concentrations were found to be within the reference values given for both groups, but higher in the subjects (p < 0.001). According to the results of patch tests, sensitivity to nickel was found to be more frequent for the subject group than the control group (p < 0.05). According to these results, clinical tools revealed no toxic effects for the subjects, except contact dermatitis. However, sensitivity to patch tests showed that this subject group has been affected compared to the control group and that this effect increased with age.
该研究的目的是测定从一个受水泥厂排放影响的农村地区采集的土壤和植物样本中的镍浓度，并确定居住在该农村地区的人群的血液镍浓度及过敏情况。该研究于2000年5月至2001年3月在土耳其埃斯基谢希尔的库库尔希萨尔镇开展。除了从水泥厂8个方向采集的108份土壤样本（36份作为对照）和植物样本外，还对该地区的258名居民（258名作为对照）进行了体格检查并采集血样，同时也进行了斑贴试验。从工厂不同方向的不同地点采集的土壤和植物样本中的镍浓度高于对照区域。除了接触性皮炎的诊断外，受试者的体格检查结果与对照组并无差异。静脉血样分析表明，两组的镍浓度均在参考值范围内，但受试者组的镍浓度更高（p<0.001）。根据斑贴试验结果，受试者组对镍过敏的情况比对照组更为常见（p<0.05）。根据这些结果，临床检查显示，除了接触性皮炎外，未发现受试者有其他毒性作用。然而，斑贴试验的过敏情况表明，与对照组相比，该受试者组受到了影响，且这种影响随年龄增长而增加。
