Akcali Zafer, Sakalli Hakan, Ozyilkan Ozgur, Demirhan Beyhan, Haberal Mehmet
Department of Medical Oncology, Baskent University Faculty of Medicine, Ankara, Turkey.
Onkologie. 2005 May;28(5):270-2. doi: 10.1159/000084652. Epub 2005 Apr 29.
Abdominal metastases with stomach involvement are rare in breast cancer. The median disease free interval from the time of breast cancer diagnosis to gastric metastasis is usually very long. Treatment is generally palliative, and expected survival time is less than 1 year.
A 59-year-old woman with breast cancer developed diffuse abdominal metastases involving stomach, abdominal lymph nodes, and omentum 9 years after she underwent mastectomy and adjuvant chemotherapy. The histopathologic diagnosis found by stomach specimen examination was invasive lobular carcinoma, and the cells expressed high levels of estrogen and progesterone receptors. The abdominal metastases were treated with surgery, postoperative chemotherapy, and further hormonal therapy. This was successful, and the patient has been in remission for more than 3 years.
Once the definitive diagnosis of breast cancer metastases to the abdomen including the stomach is established, treatment that targets systemic breast cancer must be initiated. Our patient's extended survival time suggests that surgical treatment could be considered for selected patients.
乳腺癌出现腹部转移并累及胃部的情况较为罕见。从乳腺癌诊断到发生胃转移的无病生存期通常很长。治疗一般为姑息性治疗，预期生存时间不足1年。
一名59岁的乳腺癌女性患者在接受乳房切除及辅助化疗9年后，出现了累及胃部、腹部淋巴结和大网膜的弥漫性腹部转移。通过胃标本检查得出的组织病理学诊断为浸润性小叶癌，癌细胞表达高水平的雌激素和孕激素受体。对腹部转移灶进行了手术、术后化疗及进一步的激素治疗。治疗取得成功，患者已缓解超过3年。
一旦确诊乳腺癌转移至包括胃部在内的腹部，必须启动针对全身性乳腺癌的治疗。我们患者延长的生存时间表明，对于部分患者可考虑手术治疗。
