Modestin J, Matutat B, Würmle O
University of Zurich, Department of Psychiatry, Burghölzli Hospital, Lenggstrasse 31, 8029, Zurich, Switzerland.
Eur Arch Psychiatry Clin Neurosci. 2005 Dec;255(6):419-27. doi: 10.1007/s00406-005-0592-8. Epub 2005 Apr 29.
There are similarities between alcoholics and opioid addicts and an overlap between both diagnostic groups. We tested the hypothesis that the type I and II classification, well established in male alcoholism, could also be relevant in a population of male opioid addicts.
A sample of 100 hospitalized adult opioid dependent men were studied with the help of an extended semi-structured clinical interview, considering four classification criteria sets devised by Cloninger et al. (1981, 1982), von Knorring et al. (1985, 1987), Buydens-Branchey et al. (1989) and Babor et al. (1992).
The two types of classification could be confirmed with all four criteria sets. In at least three of four analyses, 52 patients were allocated to the same larger cluster C1, and 25 patients to a smaller cluster C2. These two groups were compared with each other with the help of the stepwise discriminant analysis. Seven variables were identified which excellently discriminate between the groups: The C2 patient is younger, has a history of therapy because of depression and a history of severe suicide attempts, also abuses benzodiazepines and becomes violent while intoxicated. His father suffers from alcoholism and received treatment because of depression. The C1 patient lacks these characteristics.
The hypothesis was confirmed, showing that the two types of classification for male opioid addicts is feasible. A depressive type of male opioid dependent patient was identified. Early identification of patients of this type is clinically important.
酗酒者和阿片类药物成瘾者之间存在相似之处,且这两个诊断群体存在重叠。我们检验了这样一个假设,即在男性酗酒中已确立的I型和II型分类,在男性阿片类药物成瘾者群体中也可能适用。
借助扩展的半结构化临床访谈,对100名住院的成年阿片类药物依赖男性样本进行了研究,考虑了克隆宁格等人(1981年、1982年)、冯·诺林等人(1985年、1987年)、布伊登斯 - 布兰切等人(1989年)以及巴博尔等人(1992年)设计的四套分类标准。
所有四套标准都能证实这两种分类类型。在至少三项分析中,52名患者被归入同一个较大的C1组,25名患者被归入较小的C2组。借助逐步判别分析对这两组进行了相互比较。确定了七个能很好区分两组的变量:C2组患者更年轻,有因抑郁症接受治疗的病史和严重自杀未遂史,还滥用苯二氮䓬类药物,醉酒时会变得暴力。他的父亲患有酗酒症并因抑郁症接受过治疗。C1组患者缺乏这些特征。
该假设得到证实,表明男性阿片类药物成瘾者的两种分类是可行的。识别出了一种抑郁型男性阿片类药物依赖患者。在临床上,早期识别这类患者很重要。