Guo Johannes, Pukkala Eero, Kyyrönen Pentti, Lindbohm Marja-Liisa, Heikkilä Pirjo, Kauppinen Timo
Finnish Institute of Occupational Health, Topeliuksenk, Helsinki, Finland.
Cancer Causes Control. 2005 Mar;16(2):97-103. doi: 10.1007/s10552-004-2236-0.
To find associations between testicular cancer, occupation and chemical exposure.
A cohort of all economically active Finnish men born between 1906 and 1945 was followed-up for 19.7 million person-years during 1971-1995. Incident cases of testicular cancer (n=387) were identified in a record linkage with the Finnish Cancer Registry. The Census occupations in 1970 were converted to chemical exposures with a job-exposure matrix (FINJEM). Cumulative exposure (CE) was calculated as the product of prevalence, level, and duration of the exposure. Standardised incidence ratio (SIR) was calculated for each of the 393 occupations, and for CE categories of the 43 chemical agents, using average male population as reference. Relative risks (RR) comparing various CE-categories with unexposed ones were defined for selected agents by Poisson regression analysis.
Elevated SIRs were observed among railway traffic supervisors (5.8, 95% CI 1.6-14.7), programmers (4.3, 1.4-9.9), university teachers (4.1, 1.3-9.5) and electrical engineers (3.9, 1.1-10.1). A significant exposure-response trend (mainly contributed by seminoma) was observed for pesticides, textile dust, aliphatic and alicyclic hydrocarbons, and some other organic solvents.
Risk of testicular cancer increased only in four occupations. Pesticides, textile dust, and some organic solvents may be related to an excess risk of seminoma.
探寻睾丸癌、职业与化学物质暴露之间的关联。
对1906年至1945年出生的所有从事经济活动的芬兰男性队列进行随访，随访时间为1971年至1995年，总计1970万人年。通过与芬兰癌症登记处的记录链接确定了387例睾丸癌新发病例。利用工作暴露矩阵（FINJEM）将1970年的普查职业转换为化学物质暴露情况。累积暴露量（CE）通过暴露的患病率、水平和持续时间的乘积来计算。以男性平均人口为参照，计算了393种职业中每一种职业以及43种化学物质的CE类别中的标准化发病率（SIR）。通过泊松回归分析为选定的化学物质定义了将不同CE类别与未暴露类别进行比较的相对风险（RR）。
在铁路交通监督员（5.8，95%可信区间1.6 - 14.7）、程序员（4.3，1.4 - 9.9）、大学教师（4.1，1.3 - 9.5）和电气工程师（3.9，1.1 - 10.1）中观察到SIR升高。在农药、纺织粉尘、脂肪族和脂环族碳氢化合物以及其他一些有机溶剂方面观察到显著的暴露 - 反应趋势（主要由精原细胞瘤导致）。
仅在四种职业中睾丸癌风险增加。农药、纺织粉尘和一些有机溶剂可能与精原细胞瘤的额外风险有关。
