Gelatti Umberto, Covolo Loredana, Franceschini Michela, Pirali Francesco, Tagger Alessandro, Ribero Maria Lisa, Trevisi Paola, Martelli Claudia, Nardi Giuseppe, Donato Francesco
Department of Experimental and Applied Medicine, Chair of Hygiene, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.
J Hepatol. 2005 Apr;42(4):528-34. doi: 10.1016/j.jhep.2004.11.039.
BACKGROUND/AIMS: The role of coffee in the development of hepatocellular carcinoma (HCC) is debated. The aim of this study was to investigate the role of coffee in HCC, taking the main risk factors into account.
A hospital-based case-control study was conducted in an area of northern Italy. We recruited 250 HCC cases and 500 controls hospitalized for any reasons other than neoplasms, and liver and alcohol-related diseases. Subjects were interviewed on their lifetime history of coffee consumption using a standardized questionnaire.
Coffee consumption in the decade before the interview was associated with a decreasing risk of HCC with a clear dose-effect relation. With respect to non-drinking subjects, the odds ratios (ORs) were: 0.8, (95% CI 0.4-1.3) for 1-2 cups/day, 0.4 (95% CI 0.2-0.8) for 3-4 cups/day and 0.3 (95% CI 0.1-0.7) for 5 or more cups/day. The ORs for HCC decreased for drinking >2, compared to 0-2 cups/day of coffee, for an alcohol intake >80 g/day (OR from 5.7 to 3.3), for presence of hepatitis B virus infection (OR from 16.4 to 7.3) or hepatitis C virus infection (OR from 38.2 to 9.0).
Coffee drinking was inversely associated with HCC regardless of its aetiology.
背景/目的：咖啡在肝细胞癌（HCC）发生发展中的作用存在争议。本研究旨在考虑主要危险因素的情况下，探讨咖啡在HCC中的作用。
在意大利北部某地区开展了一项基于医院的病例对照研究。我们招募了250例HCC病例和500名因肿瘤、肝脏及酒精相关疾病以外的任何原因住院的对照。使用标准化问卷对受试者进行终生咖啡饮用史访谈。
访谈前十年的咖啡饮用与HCC风险降低相关，且存在明确的剂量效应关系。与不喝咖啡的受试者相比，每天饮用1 - 2杯咖啡的优势比（OR）为0.8（95%可信区间0.4 - 1.3），每天饮用3 - 4杯咖啡的OR为0.4（95%可信区间0.2 - 0.8），每天饮用5杯及以上咖啡的OR为0.3（95%可信区间0.1 - 0.7）。与每天饮用0 - 2杯咖啡相比，对于酒精摄入量>80克/天（OR从5.7降至3.3）、存在乙型肝炎病毒感染（OR从16.4降至7.3）或丙型肝炎病毒感染（OR从38.2降至9.0）的情况，饮用>2杯咖啡时HCC的OR降低。
无论病因如何，饮用咖啡与HCC呈负相关。
