旨在了解盘状软骨素内酯部分如何影响活性。
Toward understanding how the lactone moiety of discodermolide affects activity.
作者信息
Shaw Simon J, Sundermann Kurt F, Burlingame Mark A, Myles David C, Freeze B Scott, Xian Ming, Brouard Ignacio, Smith Amos B
机构信息
Kosan Biosciences, Inc., 3832 Bay Center Place, Hayward, CA 94545, USA.
出版信息
J Am Chem Soc. 2005 May 11;127(18):6532-3. doi: 10.1021/ja051185i.
PMID:15869264
Abstract
A series of simplified discodermolide analogues have been designed and synthesized in an attempt to understand the role of the lactone ring. These synthetic efforts have led to an unsubstituted butyrolactone 9 being generated, which shows improved activity over the natural product.
摘要
为了了解内酯环的作用，人们设计并合成了一系列简化的盘状内酯类似物。这些合成工作产生了未取代的丁内酯9，其活性比天然产物有所提高。
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