(+)-Discodermolide: Total Synthesis, Construction of Novel Analogues, and Biological Evaluation.
作者信息
Smith Amos B, Freeze B Scott
机构信息
Department of Chemistry, Monell Chemical Senses Center, Penn Center for Molecular Discovery, and Laboratory for Research on the Structure of Matter, University of Pennsylvania, Philadelphia, PA 19104.
出版信息
Tetrahedron. 2007 Jan 7;64(2):261-298. doi: 10.1016/j.tet.2007.10.039.
Abstract
摘要
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本文引用的文献
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Reactions of alkenylchromium reagents prepared from alkenyl trifluoromethanesulfonates (triflates) with chromium(II) chloride under nickel catalysis.在镍催化下，由烯基三氟甲磺酸酯（三氟甲磺酸盐）与氯化铬（II）制备的烯基铬试剂的反应。
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Coumarin-derived discodermolide analogues possessing equivalent antiproliferative activity to the natural product--a further simplification of the lactone region.具有与天然产物相当的抗增殖活性的香豆素衍生的盘状二萜内酯类似物——内酯区域的进一步简化。
Org Biomol Chem. 2007 Sep 7;5(17):2753-5. doi: 10.1039/b708884c. Epub 2007 Jul 18.
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A photoaffinity analogue of discodermolide specifically labels a peptide in beta-tubulin.盘状结构域蛋白的一种光亲和类似物特异性标记β-微管蛋白中的一种肽。
Biochemistry. 2006 Oct 3;45(39):11762-75. doi: 10.1021/bi060497a.
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Clin Cancer Res. 2006 Jan 1;12(1):298-304. doi: 10.1158/1078-0432.CCR-05-0229.
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Microtubule interactions with chemically diverse stabilizing agents: thermodynamics of binding to the paclitaxel site predicts cytotoxicity.微管与化学性质多样的稳定剂的相互作用：与紫杉醇位点结合的热力学预测细胞毒性。
Chem Biol. 2005 Dec;12(12):1269-79. doi: 10.1016/j.chembiol.2005.09.010.
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