MacDougall J D, Sale D G, Moroz J R, Elder G C, Sutton J R, Howald H
Med Sci Sports. 1979 Summer;11(2):164-6.
Needle biopsies were taken from triceps brachii of 6 healthy males before and after a 6 month intensive weight training programme. The tissue was sectioned, photographed under a Philips EM200 and subjected to stereological analysis. Cross sectional fibre areas were also calculated from cryostat sections stained for ATPase activity. Morphometric analysis indicated that training resulted in a significant 26% reduction in mitochondrial volume density and a 25% reduction in the mitochondrial volume to myofibrillar volume ratio. These changes were accompanied by significant increases in fibre area for both FT (33%) and ST (27%) fibres as determined from the light microscope. There was a significant correlation between the reduction in mitochondrial volume density and the increase in FT fibre area following training (r=0.845). It was concluded that heavy resistance training leads to a dilution of the mitochondrial volume density through an increase in myofibrillar size with hypertrophy.
在一项为期6个月的强化重量训练计划前后，从6名健康男性的肱三头肌处进行了针吸活检。将组织切片，在飞利浦EM200显微镜下拍照，并进行体视学分析。还从经ATP酶活性染色的低温恒温器切片中计算出横截面积纤维面积。形态计量学分析表明，训练导致线粒体体积密度显著降低26%，线粒体体积与肌原纤维体积之比降低25%。从光学显微镜观察，这些变化伴随着快肌纤维（FT，33%）和慢肌纤维（ST，27%）的纤维面积显著增加。训练后线粒体体积密度的降低与FT纤维面积的增加之间存在显著相关性（r=0.845）。得出的结论是，重度抗阻训练通过肌原纤维大小随肥大增加而导致线粒体体积密度稀释。
