MacDougall J D, Elder G C, Sale D G, Moroz J R, Sutton J R
Eur J Appl Physiol Occup Physiol. 1980 Feb;43(1):25-34. doi: 10.1007/BF00421352.
Seven healthy male subjects were studied under control conditions and following 5-6 months of heavy resistance training and 5-6 weeks of immobilization in elbow casts. Cross-sectional fibre areas and nuclei-to-fibre ratios were calculated from cryostat sections of needle biopsies taken from triceps brachii. Training resulted in a 98% increase in maximal elbow extension strength as measured by a Cybex dynamometer, while immobilization resulted in a 41% decrease in strength. Both fast twitch (FT) and slow twitch (ST) fibre areas increased significantly with training by 39% and 31%, respectively. Immobilization resulted in significant decreases in fibre area by 33% for FT and 25% for ST fibres. The observed nuclei-to-fibre ratio was 10% greater following the training programme. However, this change was non-significant. There was also a non-significant correlation between the magnitude of the changes in fibre size and the changes in maximal strength following either training or immobilization.
对7名健康男性受试者在对照条件下进行了研究，并在进行5 - 6个月的大强度抗阻训练以及用肘部石膏固定5 - 6周后再次进行研究。从肱三头肌针吸活检的低温切片中计算横截面积纤维和核纤维比。通过Cybex测力计测量，训练使最大伸肘力量增加了98%，而固定则使力量下降了41%。快速收缩（FT）和慢速收缩（ST）纤维面积在训练后均显著增加，分别增加了39%和31%。固定导致FT纤维面积显著减少33%，ST纤维面积减少25%。训练后观察到的核纤维比增加了10%。然而，这种变化并不显著。在训练或固定后，纤维大小变化的幅度与最大力量变化之间也存在不显著的相关性。
