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甲硝唑与胺碘酮合用导致QT间期延长和尖端扭转型室性心动过速。

QT interval prolongation and torsades de pointes due to a coadministration of metronidazole and amiodarone.

作者信息

Kounas Stavros P, Letsas Konstantinos P, Sideris Antonios, Efraimidis Michalis, Kardaras Fotios

机构信息

Second Department of Cardiology, Evagelismos Hospital, Athens, Greece.

出版信息

Pacing Clin Electrophysiol. 2005 May;28(5):472-3. doi: 10.1111/j.1540-8159.2005.09348.x.

DOI:10.1111/j.1540-8159.2005.09348.x
PMID:15869686
Abstract

This report documents the occurrence of torsades de pointes (TdP) caused by marked QT interval prolongation in the case of a 71-year-old woman receiving both metronidazole and amiodarone for the treatment of pseudomembranous colitis and paroxysmal atrial fibrillation. The case highlights a previously unknown drug interaction. The role of inhibition of cytochrome P-450 CYP3A4 is discussed.

摘要

本报告记录了一名71岁女性在接受甲硝唑和胺碘酮治疗伪膜性结肠炎和阵发性心房颤动时，因显著QT间期延长而发生尖端扭转型室速（TdP）的病例。该病例凸显了一种此前未知的药物相互作用。文中讨论了细胞色素P-450 CYP3A4抑制作用的影响。

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