Gnanapandithan Karthik, Karthik Nishrutha, Gerber Jaime
Department of Internal Medicine, Mayo Clinic, 3500 San Pablo Road S, Jacksonville, FL 32224, USA.
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.
Clin Pract. 2021 Feb 7;11(1):101-105. doi: 10.3390/clinpract11010015.
There are several classes of medications that can cause prolongation of the corrected QT (QTc) interval and potentially Torsades de Pointes (TdP). Most of these medications are commonly used in the emergency department, and interaction between these medications increases the risk of this iatrogenic complication. We describe a patient on methadone therapy who developed TdP after she received metoclopramide and metronidazole. Interaction between different classes of medications can increase the risk of QTc prolongation and TdP. Awareness of this condition and its risk factors need continuous reinforcement among all hospital personnel to reduce the risk of this life-threatening complication.
有几类药物可导致校正QT（QTc）间期延长，并可能引发尖端扭转型室速（TdP）。这些药物大多常用于急诊科，而这些药物之间的相互作用会增加这种医源性并发症的风险。我们描述了一名接受美沙酮治疗的患者，她在接受甲氧氯普胺和甲硝唑后发生了TdP。不同类药物之间的相互作用会增加QTc延长和TdP的风险。所有医院工作人员都需要持续强化对这种情况及其危险因素的认识，以降低这种危及生命并发症的风险。
