Hernandez Javier, Canby-Hagino Edith, Thompson Ian M
Department of Urology, University of Texas Health Sciences Center, A7703, Floyd Curl Drive, San Antonio, TX 78229, USA.
Curr Urol Rep. 2005 May;6(3):171-6. doi: 10.1007/s11934-005-0004-7.
Recent studies have cast doubt on the reliability of serum total prostate-specific antigen as a biomarker for the detection and prognosis of prostate cancer. Biomarkers that can identify those men at risk for clinically significant prostate cancer are desperately needed. The search for biomarkers that may improve the detection of biologically consequential prostate cancer is one of the most active areas under current investigation. In this review, we highlight some of these ongoing efforts. Proper validation of newly discovered biomarkers is of paramount importance.
近期研究对血清总前列腺特异性抗原作为前列腺癌检测和预后生物标志物的可靠性提出了质疑。迫切需要能够识别那些有患临床显著性前列腺癌风险的男性的生物标志物。寻找可能改善具有生物学意义的前列腺癌检测的生物标志物是当前研究中最活跃的领域之一。在本综述中，我们重点介绍了其中一些正在进行的工作。对新发现的生物标志物进行恰当验证至关重要。
