Wang I J, Viscidi R, Hwang K C, Lin T Y, Chen C J, Huang L M, Chen H H, Chen C J
Department of Pediatrics, Taipei Hospital, Department of Health, Taipei, Taiwan.
J Trop Pediatr. 2008 Feb;54(1):14-8. doi: 10.1093/tropej/fmm062. Epub 2007 Nov 4.
The aim of the study was to tailor a future Human papillomavirus (HPV) vaccine campaign and to help perform early primary prevention of HPV infection in Taiwan, where the incidence of cervical cancer is high. A cross-sectional survey was conducted of 826 female students, ages 10, 13, 16 and 19-22 years. A self-administered questionnaire was used to collect information on risk factors for HPV infection. Serum samples were tested for antibodies to HPV 16 capsids using a virus-like particle-based enzyme-linked immunosorbence assay. The age-adjusted odds ratio of HPV seropositivity was calculated for each risk factor by multiple logistic regression analysis. HPV 16 antibodies were detected in 13 (1.6%) of 826 participants. The HPV 16 seroprevalence was 0.35% (1/287), 0.85% (2/235), 3.2% (6/185) and 3.4% (4/119), respectively, for age groups of 10, 13, 16 and 19-22 years. In the multiple regression analysis, the history of having sexual activity was the most significant risk predictor for HPV 16 seropositivity. The seroprevalence of HPV 16 increased dramatically among high school seniors and university students, and was significantly associated with sexual activity. Vaccination against HPV is suggested to be undertaken in early adolescence, before 16 years of age and prior to sexual debut.
该研究的目的是定制未来的人乳头瘤病毒（HPV）疫苗接种活动，并帮助在宫颈癌发病率较高的台湾地区开展HPV感染的早期一级预防。对826名年龄在10岁、13岁、16岁以及19至22岁的女学生进行了横断面调查。采用自填式问卷收集HPV感染危险因素的信息。使用基于病毒样颗粒的酶联免疫吸附测定法检测血清样本中针对HPV 16衣壳的抗体。通过多重逻辑回归分析计算每个危险因素的年龄调整后HPV血清阳性比值比。在826名参与者中，有13人（1.6%）检测到HPV 16抗体。10岁、13岁、16岁以及19至22岁年龄组的HPV 16血清阳性率分别为0.35%（1/287）、0.85%（2/235）、3.2%（6/185）和3.4%（4/119）。在多重回归分析中，有性行为史是HPV 16血清阳性最显著的风险预测因素。HPV 16血清阳性率在高中高年级学生和大学生中显著增加，且与性行为显著相关。建议在青春期早期、16岁之前以及首次性行为之前接种HPV疫苗。
