Davidson A E, Miller S D, Settipane R J, Ricci A R, Klein D E, Settipane G A
Rhode Island Hospital Division of Allergy and Immunology, Providence 02903.
Allergy Proc. 1992 Mar-Apr;13(2):81-4. doi: 10.2500/108854192778878854.
This study investigated nasal mucociliary clearance as related to nasal eosinophilia in nonallergic rhinitis patients using the technique of nasal saccharin challenge. Fifty-six consecutive patients with nonallergic rhinitis were evaluated with nasal cytology and saccharin challenge. A saccharin challenge time of greater than 25 minutes was considered abnormal. Twelve of 56 patients (21.4%) had nasal eosinophilia. Fifteen of 56 patients (26.8%) had prolonged nasal circulation times greater than 25 minutes, indicating delayed mucociliary clearance. Although 7 of 12 patients (58.3%) with nasal eosinophilia had delayed mucociliary clearance, only 8 of 44 patients (18.2%) without eosinophilia had circulation times longer than 25 minutes. The correlation of nasal eosinophilia with prolongation of the nasal circulation time is statistically significant (chi square 5.84, P = .0156). We postulate that damage to the nasal mucociliary system may be an etiologic factor for a subset of patients with nonallergic rhinitis and that this damage may be mediated by eosinophils.
本研究采用鼻内糖精激发技术，调查了非变应性鼻炎患者鼻黏膜纤毛清除功能与鼻内嗜酸性粒细胞增多的关系。对56例连续性非变应性鼻炎患者进行了鼻细胞学检查和糖精激发试验。糖精激发时间超过25分钟被视为异常。56例患者中有12例（21.4%）存在鼻内嗜酸性粒细胞增多。56例患者中有15例（26.8%）鼻循环时间延长超过25分钟，表明黏膜纤毛清除功能延迟。虽然12例鼻内嗜酸性粒细胞增多患者中有7例（58.3%）存在黏膜纤毛清除功能延迟，但44例无嗜酸性粒细胞增多的患者中只有8例（18.2%）循环时间超过25分钟。鼻内嗜酸性粒细胞增多与鼻循环时间延长之间的相关性具有统计学意义（卡方值5.84，P = 0.0156）。我们推测，鼻黏膜纤毛系统受损可能是非变应性鼻炎部分患者的病因，且这种损伤可能由嗜酸性粒细胞介导。
