Mahakit P, Pumhirun P
Department of Otolaryngology, Pramongkutklao College of Medicine, Bangkok, Thailand.
Asian Pac J Allergy Immunol. 1995 Dec;13(2):119-21.
Mucocillary clearance of nasal mucosa was evaluated with the saccharin test. A total of 140 subjects was divided into 4 groups: smokers, allergic rhinitis patients, sinusitis patients, and a normal control group. The mean mucociliary transit time for the normal control group (n = 40) was 12 minutes, while allergic rhinitis patients (n = 40) had a mean of 14.6 minutes. The smoker group (n = 40) could be further divided into the following subcategories: (a) those who had been smoking for less than 5 years (n = 10) had a mean of 15.2 minutes, (b) those who had been smoking for more than 5 years at less than one-pack a day (n = 11) had a mean of 14 minutes, and (c) those who had been smoking for more than 5 years at more than one-pack a day (n = 19) had a mean of 16.5 minutes. For the sinusitis patients (n = 20) the mean was 16.6 minutes. The study shows that sinusitis patients, along with those smokers who had been smoking for more than 5 years at more than one-pack a day, had a mucocillary transit time that was considered to be prolonged when compared to the normal control group (p < 0.05).
采用糖精试验评估鼻黏膜的黏液纤毛清除功能。总共140名受试者被分为4组：吸烟者、变应性鼻炎患者、鼻窦炎患者和正常对照组。正常对照组（n = 40）的平均黏液纤毛传输时间为12分钟，而变应性鼻炎患者（n = 40）的平均时间为14.6分钟。吸烟组（n = 40）可进一步分为以下亚组：（a）吸烟少于5年者（n = 10），平均时间为15.2分钟；（b）吸烟超过5年且每天吸烟少于1包者（n = 11），平均时间为14分钟；（c）吸烟超过5年且每天吸烟超过1包者（n = 19），平均时间为16.5分钟。鼻窦炎患者（n = 20）的平均时间为16.6分钟。研究表明，与正常对照组相比，鼻窦炎患者以及每天吸烟超过1包且吸烟超过5年的吸烟者，其黏液纤毛传输时间被认为延长（p < 0.05）。
