Nenoff P, Domula E, Willing U, Herrmann J
Laboratorium für medizinische Mikrobiologie, Mölbis.
Hautarzt. 2006 Jun;57(6):518-20, 521-2. doi: 10.1007/s00105-005-0959-9.
Three patients with chronic urticaria or pruritus were found to suffer from an asymptomatic intestinal infection caused by the protozoan Giardia lamblia. Treatment with metronidazole per os or tinidazole per os was successful; the pruritic symptoms in one patient improved markedly.Giardia lamblia (Giardia intestinalis) are enteroparasites and produce gastrointestinal symptoms such as acute and chronic diarrhea. Cutaneous manifestations associated with giardiasis occur extremely rarely. Urticaria and itching may be explained as an infection-associated allergy. Hitherto, the following cutaneous signs have been described: urticaria, angioedema, mouth ulcers, pruritus, atopic dermatitis, and anal eczema.We considered that the cutaneous manifestations described here, i. e., urticaria and itching, were secondary to the associated gastrointestinal infection due to Giardia lamblia cysts and trophozoite forms, as they disappeared under specific treatment with metronidazole or tinidazole.
三名患有慢性荨麻疹或瘙痒症的患者被发现感染了由原生动物蓝氏贾第鞭毛虫引起的无症状肠道感染。口服甲硝唑或替硝唑治疗成功；一名患者的瘙痒症状明显改善。蓝氏贾第鞭毛虫（肠贾第虫）是肠道寄生虫，可引起急性和慢性腹泻等胃肠道症状。与贾第虫病相关的皮肤表现极为罕见。荨麻疹和瘙痒可能被解释为感染相关的过敏反应。迄今为止，已描述了以下皮肤体征：荨麻疹、血管性水肿、口腔溃疡、瘙痒、特应性皮炎和肛门湿疹。我们认为此处描述的皮肤表现，即荨麻疹和瘙痒，是由蓝氏贾第鞭毛虫囊肿和滋养体形式引起的相关胃肠道感染的继发症状，因为它们在甲硝唑或替硝唑的特定治疗下消失了。
