Erel F, Sener O, Erdil A, Karaayvaz M, Gür G, Caliskaner Z, Ozangüç N
GATA, Allergy Department, Ankara, Turkey.
J Investig Allergol Clin Immunol. 2000 Mar-Apr;10(2):94-7.
The etiology of chronic urticaria is largely unknown. The role of Helicobacter pylori infection, which is the most important cause of gastritis and peptic ulcer, is not clear in the pathophysiology of chronic urticaria. In this study, we aimed to define the impact of H. pylori on chronic urticaria. Thirty-eight patients who had chronic urticaria of unknown origin and dyspepsia were included in the study. In all patients, standard laboratory tests for detection of urticaria etiology were performed. Mean urticaria symptom scores of patients were carried out. All patients underwent upper gastrointestinal endoscopy. The presence of H. pylori was investigated using urease testing and histopathology. Duodenal fluid aspirated during upper endoscopy was examined for the presence of Giardia lamblia. H. pylori infection was detected in 29 patients. After successful eradication of H. pylori infection, the mean symptom score of patients did not change significantly (2.6 +/- 0.6 vs., 2.4 +/- 0.8). Only one patient had a total disappearance of urticaria symptoms. Out of 38 patients, only one had G. lamblia infection. The results of our study suggest that there is no association between H. pylori infection and chronic urticaria.
慢性荨麻疹的病因大多不明。幽门螺杆菌感染是胃炎和消化性溃疡的最重要病因，但其在慢性荨麻疹病理生理学中的作用尚不清楚。在本研究中，我们旨在明确幽门螺杆菌对慢性荨麻疹的影响。38例不明原因慢性荨麻疹且有消化不良症状的患者纳入研究。对所有患者进行了检测荨麻疹病因的标准实验室检查。记录患者的平均荨麻疹症状评分。所有患者均接受了上消化道内镜检查。采用尿素酶试验和组织病理学检查幽门螺杆菌的存在情况。对上消化道内镜检查时抽取的十二指肠液进行检查，以确定是否存在蓝氏贾第鞭毛虫。29例患者检测到幽门螺杆菌感染。成功根除幽门螺杆菌感染后，患者的平均症状评分无显著变化（2.6±0.6对2.4±0.8）。仅1例患者荨麻疹症状完全消失。38例患者中，仅1例有蓝氏贾第鞭毛虫感染。我们的研究结果表明，幽门螺杆菌感染与慢性荨麻疹之间无关联。
