铁催化的简单芳基镁试剂和官能化芳基镁试剂的均偶联反应。

Iron-catalyzed homo-coupling of simple and functionalized arylmagnesium reagents.

作者信息

Cahiez Gérard, Chaboche Christophe, Mahuteau-Betzer Florence, Ahr Mathieu

机构信息

Laboratoire de Synthèse Organique Sélective et de Chimie Organométallique (SOSCO), UMR 8123 CNRS-UCP-ESCOM, Cergy-Pontoise, France.

出版信息

Org Lett. 2005 May 12;7(10):1943-6. doi: 10.1021/ol050340v.

DOI:10.1021/ol050340v

PMID:15876025

Abstract

Iron-catalyzed homo-coupling of simple and functionalized arylmagnesium reagents is described. The reaction is highly chemoselective (CN, COOEt and NO(2) groups are tolerated). The procedure was used to perform intramolecular couplings. This cyclization reaction is the key step of the total synthesis of the N-methylcrinasiadine.

摘要

本文描述了铁催化的简单芳基镁试剂和官能化芳基镁试剂的均偶联反应。该反应具有高度的化学选择性（氰基、乙酯基和硝基等基团均可耐受）。此方法被用于进行分子内偶联反应。该环化反应是N-甲基crinasiadine全合成的关键步骤。