铁催化的 N-杂环氯化物和溴化物与芳基镁试剂的交叉偶联。
Iron-catalyzed cross-coupling of N-heterocyclic chlorides and bromides with arylmagnesium reagents.
机构信息
Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377 München, Germany.
出版信息
Org Lett. 2012 Sep 21;14(18):4818-21. doi: 10.1021/ol302136c. Epub 2012 Sep 11.
PMID:22966964
Abstract
A simple, practical iron salt catalyzed procedure allows fast cross-couplings of N-heterocyclic chlorides and bromides with various electron-rich and -poor arylmagnesium reagents. A solvent mixture of THF and tBuOMe is found to be essential for achieving high yields mainly by avoiding homocoupling side reactions.
摘要
一种简单实用的铁盐催化方法，可快速实现 N-杂环氯化物和溴化物与各种富电子和缺电子芳基镁试剂的交叉偶联。发现 THF 和 tBuOMe 的溶剂混合物对于获得高产率是必不可少的，主要是通过避免同偶联副反应。
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