病毒载体在植物疫苗生产中的应用。
Use of viral vectors for vaccine production in plants.
作者信息
Cañizares M Carmen, Nicholson Liz, Lomonossoff George P
机构信息
John Innes Centre, Norwich, UK.
出版信息
Immunol Cell Biol. 2005 Jun;83(3):263-70. doi: 10.1111/j.1440-1711.2005.01339.x.
Abstract
The small size of plant viral genomes, the ease with which they can be manipulated, and the simplicity of the infection process is making the viral vectors an attractive alternative to the transgenic systems for the expression of foreign proteins in plants. One use of these virus expression systems is for vaccine production. There are two basic types of viral system that have been developed for the production of immunogenic peptides and proteins in plants: epitope presentation and polypeptide expression systems. In this review, we discuss advances made in this field.
摘要
植物病毒基因组规模小、易于操作，且感染过程简单，这使得病毒载体成为在植物中表达外源蛋白的转基因系统的一个有吸引力的替代方案。这些病毒表达系统的一种用途是用于疫苗生产。为在植物中生产免疫原性肽和蛋白质，已开发出两种基本类型的病毒系统：表位展示系统和多肽表达系统。在本综述中，我们讨论了该领域取得的进展。
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