Skalova Sylva, Dedek Petr, Pozler Oldrich, Podhola Miroslav
Department of Pediatrics, Charles University in Prague, Faculty of Medicine and University Hospital in Hradec Králové, Czech Republic.
Ren Fail. 2009;31(2):159-61. doi: 10.1080/08860220802595922.
5-aminosalicylate compounds (mesalazine, sulfasalazine) are widely used in therapy of inflammatory bowel diseases. Mesalazine-induced interstitial nephritis is a rare complication; however, the morbidity in an affected individual is high. Regular renal screening in patients treated with 5-aminosalicylate compounds is important. A 15-year-old boy with treated idiopathic proctocolitis, consequent mesalazine-induced nephritis, and a favorable response to corticotherapy is presented.
5-氨基水杨酸盐化合物（美沙拉嗪、柳氮磺胺吡啶）广泛用于炎症性肠病的治疗。美沙拉嗪诱发的间质性肾炎是一种罕见的并发症；然而，在受影响个体中的发病率很高。对接受5-氨基水杨酸盐化合物治疗的患者进行定期肾脏筛查很重要。本文介绍了一名15岁男孩，患有经治疗的特发性直肠结肠炎、继发美沙拉嗪诱发的肾炎，且对皮质激素治疗反应良好。
