Leary S M, Porter B, Thompson A J
Rehabilitation Group, Institute of Neurology, Queen Square, London, UK.
Postgrad Med J. 2005 May;81(955):302-8. doi: 10.1136/pgmj.2004.029413.
Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system that may result in a wide range of neurological symptoms and accumulating disability. Its course is unpredictable resulting in a changing pattern of clinical need. Diagnostic criteria for multiple sclerosis require objective evidence for dissemination in space and time. The diagnostic and management process should follow good practice guidelines with the person at the centre of the process. Appropriate support and information should be available from the time of diagnosis. Continuing education is key in enabling the person to actively participate in their management. In the event of an acute relapse the person should have direct access to the most appropriate local service. Provided medical causes have been excluded, corticosteroid treatment to hasten the recovery from the relapse should be considered. Management of an acute relapse should be comprehensive addressing any medical, functional, or psychosocial sequelae.
多发性硬化症是一种中枢神经系统的炎性脱髓鞘疾病，可能导致广泛的神经症状和残疾累积。其病程不可预测，导致临床需求模式不断变化。多发性硬化症的诊断标准需要有在空间和时间上播散的客观证据。诊断和管理过程应遵循良好实践指南，将患者置于过程的中心。从诊断之时起就应提供适当的支持和信息。继续教育是使患者能够积极参与自身管理的关键。在急性复发的情况下，患者应能直接获得最合适的当地服务。如果已排除医学原因，应考虑使用皮质类固醇治疗以加速从复发中恢复。急性复发的管理应全面，解决任何医学、功能或心理社会后遗症。
