Kim Hyeonjin, McGrath Brent M, Silverstone Peter H
Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada.
Hum Psychopharmacol. 2005 Jul;20(5):309-26. doi: 10.1002/hup.693.
Myo-inositol is an important part of the phosphatidylinositol second messenger system (PI-cycle). Abnormalities in nerve cell myo-inositol levels and/or PI-cycle regulation has been suggested as being involved in the pathophysiology and/or treatment of many psychiatric disorders including bipolar disorder, major depressive disorder, panic disorder, obsessive-compulsive disorder, eating disorders and schizophrenia. This review examines the metabolism and biochemical importance of myo-inositol and the PI-cycle. It relates this to the current in vivo evidence for myo-inositol and PI-cycle involvement in these psychiatric disorders, particularly focusing upon the magnetic resonance spectroscopy (MRS) findings in patient studies to date. From this review it is concluded that while the evidence suggests probable relevance to the pathophysiology and/or treatment of bipolar disorder, there is much less support for a significant role for the PI-cycle or myo-inositol in any other psychiatric disorder. More definitive investigation is required before PI-cycle dysfunction can be considered specific to bipolar disorder.
肌醇是磷脂酰肌醇第二信使系统（PI 循环）的重要组成部分。神经细胞中肌醇水平和/或 PI 循环调节异常被认为与包括双相情感障碍、重度抑郁症、恐慌症、强迫症、饮食失调和精神分裂症在内的许多精神疾病的病理生理学和/或治疗有关。本综述探讨了肌醇和 PI 循环的代谢及生化重要性。它将此与目前关于肌醇和 PI 循环参与这些精神疾病的体内证据相关联，特别关注迄今为止患者研究中的磁共振波谱（MRS）结果。从本综述得出的结论是，虽然证据表明可能与双相情感障碍的病理生理学和/或治疗相关，但对于 PI 循环或肌醇在任何其他精神疾病中的重要作用，支持力度要小得多。在将 PI 循环功能障碍视为双相情感障碍所特有的情况之前，需要进行更明确的研究。
