Dhong Hun-Jong, Kim Hyo Y, Cho Do-Yeon
Department of Otorhinolaryngology--Head and Neck Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, South Korea.
Acta Otolaryngol. 2005 Feb;125(2):169-76. doi: 10.1080/00016480410015767.
These findings suggest that patients with both sinusitis and asthma present the histopathologic characteristic of a marked chronic inflammatory reaction, and that eosinophil infiltration may play a significant role in this marked inflammation of the sinus mucosa.
Chronic sinusitis and bronchial asthma are known to be closely related. However, the appearance of the mucosa in chronic sinusitis patients with asthma is somewhat different from that in patients without asthma. MATERIAL AND METHODS. We compared the sinus mucosal histopathologies of asthmatic patients with those of non-asthmatic patients. Fifty-three sinusitis patients with a diagnosis of asthma and 54 sinusitis patients without asthma, who served as controls, were enrolled in the study. All of these patients underwent endoscopic sinus surgery. The following seven light microscopic findings were compared in the asthmatic and non-asthmatic groups: the thickness of the basement membrane, goblet cell hyperplasia, subepithelial edema, submucous gland formation, eosinophil infiltration, lymphocyte infiltration and polymorphonuclear leukocyte infiltration. In addition, we explored a possible link between asthma and sinusitis by comparing the following factors in asthmatic and non-asthmatic patients: the presence of allergy, the degree of preoperative polyposis and the extent of preoperative disease as scored by means of ostiomeatal unit CT findings.
No statistically significant differences were found between the two groups in terms of the presence of allergy, the degree of preoperative polyposis or the extent of preoperative disease. Basement membrane thickening, goblet cell hyperplasia and eosinophil infiltration were more prominent in the asthmatic compared to the non-asthmatic group (p <0.05).
这些发现表明，患有鼻窦炎和哮喘的患者呈现出明显慢性炎症反应的组织病理学特征，并且嗜酸性粒细胞浸润可能在鼻窦黏膜的这种明显炎症中起重要作用。
已知慢性鼻窦炎和支气管哮喘密切相关。然而，患有哮喘的慢性鼻窦炎患者的黏膜外观与无哮喘患者的黏膜外观有所不同。材料与方法。我们比较了哮喘患者与非哮喘患者的鼻窦黏膜组织病理学。本研究纳入了53例诊断为哮喘的鼻窦炎患者和54例作为对照的无哮喘鼻窦炎患者。所有这些患者均接受了鼻内镜鼻窦手术。在哮喘组和非哮喘组中比较了以下七个光镜下表现：基底膜厚度、杯状细胞增生、上皮下水肿、黏膜下腺体形成、嗜酸性粒细胞浸润、淋巴细胞浸润和多形核白细胞浸润。此外，我们通过比较哮喘患者和非哮喘患者的以下因素来探索哮喘与鼻窦炎之间可能的联系：过敏的存在、术前息肉形成程度以及通过窦口鼻道复合体CT表现评分的术前疾病范围。
两组在过敏的存在、术前息肉形成程度或术前疾病范围方面未发现统计学上的显著差异。与非哮喘组相比，哮喘组的基底膜增厚、杯状细胞增生和嗜酸性粒细胞浸润更为明显（p<0.05）。
