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同时患有精神分裂症和物质使用障碍的长期患者的三年康复结果。

Three-year recovery outcomes for long-term patients with co-occurring schizophrenic and substance use disorders.

作者信息

Xie Haiyi, McHugo Gregory J, Helmstetter Barbara S, Drake Robert E

机构信息

Departments of Psychiatry and Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03766, USA.

出版信息

Schizophr Res. 2005 Jun 15;75(2-3):337-48. doi: 10.1016/j.schres.2004.07.012.

Abstract

Little is known about the expected treatment outcomes of patients with co-occurring schizophrenic and substance use disorders. This paper reports 3-year outcomes for 152 patients with schizophrenia or schizoaffective disorder and substance use disorders, all of whom received integrated dual disorders treatments in the New Hampshire Dual Diagnosis Study. Outcomes are defined as positive coping behaviors identified by consumers as indicators of recovery. Participants improved steadily in terms of controlling symptoms of schizophrenia, actively attaining remissions from substance abuse, increasing competitive employment, increasing social contacts with non-substance abusers, and improving life satisfaction. Though successful in reducing hospitalization and homelessness, they did not increase time in independent living situations. Outcomes were only weakly interrelated, suggesting that recovery is a multidimensional concept. Neither psychotic diagnosis (schizophrenia vs. schizoaffective disorder) nor substance abuse diagnosis (alcohol vs. other drug disorder vs. both) was related to outcomes. However, these patients with co-occurring schizophrenic and substance use disorders did significantly less well than patients with co-occurring bipolar and substance use disorders in terms of hospitalization, independent living, and quality of life. Overall, the findings provide a hopeful long-term perspective for dual diagnosis patients.

摘要

对于同时患有精神分裂症和物质使用障碍的患者,其预期治疗结果鲜为人知。本文报告了152例患有精神分裂症或分裂情感性障碍以及物质使用障碍患者的3年治疗结果,这些患者均在新罕布什尔双诊断研究中接受了综合双障碍治疗。结果被定义为消费者确定的作为康复指标的积极应对行为。参与者在控制精神分裂症症状、积极实现药物滥用缓解、增加竞争性就业、增加与非药物滥用者的社交接触以及提高生活满意度方面稳步改善。尽管在减少住院和无家可归方面取得了成功,但他们独立生活的时间并未增加。各项结果之间的关联性较弱,这表明康复是一个多维度的概念。精神病诊断(精神分裂症与分裂情感性障碍)和物质滥用诊断(酒精与其他药物障碍或两者皆有)均与结果无关。然而,这些同时患有精神分裂症和物质使用障碍的患者在住院、独立生活和生活质量方面的表现明显不如同时患有双相情感障碍和物质使用障碍的患者。总体而言,这些研究结果为双诊断患者提供了一个充满希望的长期前景。

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