Drake Robert E, McHugo Gregory J, Xie Haiyi, Fox Melinda, Packard Joan, Helmstetter Barbara
Departmetn of Psychiatry, Dartmouth Medical School, USA.
Schizophr Bull. 2006 Jul;32(3):464-73. doi: 10.1093/schbul/sbj064. Epub 2006 Mar 8.
The long-term courses of people with schizophrenia and of those with substance use disorder have been studied separately and extensively. The long-term course of clients with co-occurring schizophrenic and substance use disorders has, however, not been examined. This article reports 10-year outcomes for 130 clients with co-occurring schizophrenic and substance use disorders in the New Hampshire Dual Diagnosis Study. In addition, we report on 6 "recovery outcomes," identified by dual diagnosis clients, as examples of positive coping behaviors. Longitudinal data were modeled using generalized estimating equation (GEE) methods. Participants improved steadily over 10 years in the outcome domains of symptoms, substance abuse, institutionalization, functional status, and quality of life. Further, at the 10-year follow-up, substantial proportions were above cutoffs selected by dual diagnosis clients as indicators of recovery: 62.7% were controlling symptoms of schizophrenia; 62.5% were actively attaining remissions from substance abuse; 56.8% were in independent living situations; 41.4% were competitively employed; 48.9% had regular social contacts with non-substance abusers; and 58.3% expressed overall life satisfaction. These 6 outcomes were only weakly interrelated over time, suggesting that recovery, as defined by clients, is a multidimensional concept. Overall, the 10-year findings on recovery outcomes provide a hopeful long-term perspective for dual diagnosis clients.
精神分裂症患者和物质使用障碍患者的长期病程已分别得到广泛研究。然而,同时患有精神分裂症和物质使用障碍的患者的长期病程尚未得到研究。本文报告了新罕布什尔双重诊断研究中130例同时患有精神分裂症和物质使用障碍的患者的10年随访结果。此外,我们报告了双重诊断患者确定的6项“康复结果”,作为积极应对行为的示例。纵向数据采用广义估计方程(GEE)方法进行建模。参与者在症状、药物滥用、住院治疗、功能状态和生活质量等结果领域在10年中稳步改善。此外,在10年随访时,相当大比例的患者超过了双重诊断患者选定的作为康复指标的临界值:62.7%的患者控制了精神分裂症症状;62.5%的患者积极实现了药物滥用缓解;56.8%的患者独立生活;41.4%的患者有竞争性就业;48.9%的患者与非药物滥用者有定期社交接触;58.3%的患者表示总体生活满意。随着时间的推移,这6项结果之间的相关性较弱,这表明患者所定义的康复是一个多维概念。总体而言,关于康复结果的10年研究结果为双重诊断患者提供了一个充满希望的长期前景。