[脑去甲肾上腺素和5-羟色胺水平降低对大鼠防御性和获取食物条件反射的影响]
[Effect of a decrease in brain noradrenaline and serotonin levels on defensive and food-getting conditioned reflexes in rats].
作者信息
Staĭkova R M, Orlova N V, Getsova V M
出版信息
Zh Vyssh Nerv Deiat Im I P Pavlova. 1979 Sep-Oct;29(5):962-9.
The influence of pharmacological and surgical interferences in the activity of serotoninergic and catecholaminergic brain systems on elaboration and consolidation of conditioned reflexes was studied in rats. Ablation of the locus coeruleus, nucleus raphe and administration of inhibitors of monoamines synthesis reduced noradrenaline and serotonin (5-OT) content in rat's brain. Ablation of the locus coeruleus and disulphiram administration impaired mainly the elaboration of defensive and alimentary conditioned reflexes. Ablation of the nucleus raphe and parachlorphenilalanin administration affected predominantly the retention of the reflexes. At the same time, the effects of surgical and pharmacological interferences differed in some respects
在大鼠中研究了药物和手术干预对血清素能和儿茶酚胺能脑系统活性的影响，以及对条件反射的形成和巩固的影响。蓝斑、中缝核的切除以及单胺合成抑制剂的给药降低了大鼠脑中去甲肾上腺素和血清素（5-羟色胺）的含量。蓝斑切除和双硫仑给药主要损害防御性和食物性条件反射的形成。中缝核切除和对氯苯丙氨酸给药主要影响反射的保持。同时，手术和药物干预的效果在某些方面有所不同。
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