Gatti A, Munari L, Perretti A, Porta M, Altamura C, Ragazzetti M G
Divisione di Neurologia, Policlinico San Marco, Zingonia, Bergamo.
Minerva Med. 1992 May;83(5):277-81.
Alcohol abstinence syndrome (AAS) occurs in alcohol dependent patients a few hours after ceasing to drink, first in the form of gastrointestinal and dysvegetative signs, then with the involvement of neurological functions. The results obtained in 15 patients selected according to DSM III criteria, treated with nimodipine (calcium entry blocker) in the acute phase and with reduced glutathione in the subacute phase are presented. All patients who, during treatment, did not take other drugs, showed a definite, fast improvement in symptoms, especially in neurovegetative symptoms. Administration of nimodipine, which seems capable of reducing the catecholaminergic drive, was very well tolerated. Treatment with reduced glutathione is justified by the fact that the inadequate intake of alcohol is responsible for liver changes and, particularly, for a significant reduction in liver levels of glutathione, a condition that makes the cell more exposed to attack on the part of substances that activate lipoperoxidation processes. The results obtained seem to confirm a protective action on the part of reduced glutathione.
酒精戒断综合征（AAS）发生在酒精依赖患者停止饮酒后的数小时内，最初表现为胃肠道和自主神经功能紊乱症状，随后累及神经功能。本文呈现了根据《精神疾病诊断与统计手册》第三版（DSM III）标准选取的15例患者的治疗结果，这些患者在急性期接受尼莫地平（钙通道阻滞剂）治疗，亚急性期接受还原型谷胱甘肽治疗。所有在治疗期间未服用其他药物的患者，症状均有明确且快速的改善，尤其是神经自主症状。尼莫地平似乎能够降低儿茶酚胺能驱动力，其耐受性良好。使用还原型谷胱甘肽进行治疗的依据是，酒精摄入不足会导致肝脏变化，特别是肝脏中谷胱甘肽水平显著降低，这种情况会使细胞更容易受到激活脂质过氧化过程的物质的攻击。所获得的结果似乎证实了还原型谷胱甘肽具有保护作用。
