来自橙色马尔布兰奇霉菌的植物毒素。

Phytotoxins from the fungus Malbranchea aurantiaca.

作者信息

Martínez-Luis Sergio, González María C, Ulloa Miguel, Mata Rachel

机构信息

Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, D.F. 04510, México.

出版信息

Phytochemistry. 2005 May;66(9):1012-6. doi: 10.1016/j.phytochem.2005.03.005.

DOI:10.1016/j.phytochem.2005.03.005

PMID:15896370

Abstract

Bioassay-directed fractionation of an ethyl acetate extract from cultures of the fungus Malbranchea aurantiaca led to the isolation of two phytotoxic compounds, namely, 1-hydroxy-2-oxoeremophil-1(10),7(11),8(9)-trien-12(8)-olide (1) and penicillic acid (2). The structure of 1 was established by spectroscopic and X-ray crystallographic analyses. Metabolites 1 and 2 caused significant inhibition of radicle growth of Amaranthus hypochondriacus with IC(50) values 6.57 and 3.86 microM, respectively. In addition, 1 inhibited activation of the calmodulin-dependent enzyme cAMP phosphodiesterase (IC(50)=10.2 microM).

摘要

对橙色马尔布兰奇霉菌培养物的乙酸乙酯提取物进行生物测定导向的分级分离，得到了两种具有植物毒性的化合物，即1-羟基-2-氧代桉叶-1(10),7(11),8(9)-三烯-12(8)-内酯（1）和青霉酸（2）。通过光谱分析和X射线晶体学分析确定了1的结构。代谢产物1和2对皱果苋胚根生长有显著抑制作用，IC(50)值分别为6.57和3.86微摩尔。此外，1抑制钙调蛋白依赖性酶cAMP磷酸二酯酶的激活（IC(50)=10.2微摩尔）。