从盐土中分离得到的真菌中的新布替内酯和环戊烯酮。
New Butenolides and Cyclopentenones from Saline Soil-Derived Fungus .
机构信息
College of Pharmacy, Binzhou Medical University, Yantai 264003, China.
Beijing Higher Institution Engineering Research Center of Food Additives and Ingredients, Beijing Key Laboratory of Flavor Chemistry, Beijing Laboratory for Food Quality and Safety, Beijing Technology and Business University, Beijing 100048, China.
出版信息
Molecules. 2019 Jul 21;24(14):2642. doi: 10.3390/molecules24142642.
Three new -hydroxyl butenolides (-), a pair of new enantiomeric spiro-butenolides ( and ), a pair of enantiomeric cyclopentenones ( new and new natural), and six known compounds (-), were isolated from . Their structures were established by spectroscopic data and electronic circular dichroism (ECD) spectra. Two pairs of enantiomers [(+)/(-)- and (+)/(-)-] obtained from the reaction of with acetyl chloride (AcCl) confirmed that was a mixture of two pairs of enantiomers. In addition, the X-ray data confirmed that was also a racemate. The new metabolites (- were evaluated for their inhibitory activity against cancer and non-cancer cell lines. As a result, compound exhibited moderate cytotoxicity to HL60 and A549 with IC values of 6.5 and 8.9 µM, respectively, and weak potency to HL-7702 with IC values of 17.6 µM. Furthermore, compounds - were screened for their antimicrobial activity using the micro-broth dilution method. MIC values of 200 μg/mL were obtained for compounds and towards and , while compound exhibited a MIC of 50 μ/mL towards .
从 中分离得到 3 个新的 -羟基丁烯内酯（-）、1 对新的对映体螺环丁烯内酯（和）、1 对新的对映体环戊烯酮（新和 新天然）和 6 个已知化合物（-）。通过光谱数据和电子圆二色性（ECD）光谱确定了它们的结构。从与乙酰氯（AcCl）的反应中获得的两对对映异构体[(+)/(−)-和(+)/(−)-]证实了 是两对对映异构体的混合物。此外，X 射线数据证实也是外消旋体。对新代谢产物（-）进行了抗癌和非癌细胞系抑制活性的评价。结果表明，化合物 对 HL60 和 A549 的细胞毒性分别为 6.5 和 8.9 μM，对 HL-7702 的活性较弱，IC 值为 17.6 μM。此外，采用微量肉汤稀释法对化合物 - 进行了抗菌活性筛选。化合物 和 对 和 的 MIC 值为 200 μg/mL，而化合物 对 的 MIC 值为 50 μ/mL。
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