在用静脉注射戊烷脒异硫氰酸盐治疗卡氏肺孢子虫肺炎期间发生心脏骤停。

Cardiac arrest during treatment of Pneumocystis carinii pneumonia with intravenous pentamidine isethionate.

作者信息

Balslev U, Berild D, Nielsen T L

机构信息

Department of Infectious Diseases, Hvidovre Hospital, University of Copenhagen, Denmark.

出版信息

Scand J Infect Dis. 1992;24(1):111-2. doi: 10.3109/00365549209048410.

DOI:10.3109/00365549209048410

PMID:1589716

Abstract

A 27-year-old man, HIV-positive for 4 years, developed ventricular fibrillation and cardiac arrest during treatment of Pneumocystis carinii pneumonia with intravenous pentamidine isethionate. The dosage was 4 mg/kg/day for 18 days. Nephrotoxicity occurred and raised serum potassium. The plasma concentration of pentamidine was 580 nmol/l. Careful monitoring of renal and cardiac functions is recommended during intravenous therapy with pentamidine isethionate.

摘要

一名27岁男性，HIV阳性4年，在接受静脉注射戊烷脒异硫氰酸盐治疗卡氏肺孢子虫肺炎期间发生室颤和心脏骤停。剂量为4mg/kg/天，持续18天。出现肾毒性并导致血清钾升高。戊烷脒的血浆浓度为580nmol/l。建议在静脉注射戊烷脒异硫氰酸盐治疗期间仔细监测肾功能和心功能。