Green P T, Reents S, Harman E, Curtis A B
Department of Medicine, University of Florida, Gainesville.
South Med J. 1990 Apr;83(4):481-4. doi: 10.1097/00007611-199004000-00031.
Pentamidine isethionate, an important agent used to treat Pneumocystis carinii pneumonia, has been shown to be associated with the development of torsades de pointes in patients with AIDS. We have described a case of pentamidine-induced polymorphous ventricular tachycardia in a renal transplant recipient whose renal insufficiency may have prolonged the duration of arrhythmias. Careful ECG monitoring should be done during pentamidine administration, especially in patients with renal insufficiency. Physicians should be aware that this variety of polymorphous ventricular tachycardia can occur well within the recommended dose of pentamidine. More data are needed to define the relationship between renal dysfunction, plasma levels, and pentamidine cardiotoxicity.
喷他脒异硫氰酸盐是一种用于治疗卡氏肺孢子虫肺炎的重要药物，已被证明与艾滋病患者发生尖端扭转型室速有关。我们描述了一例肾移植受者发生喷他脒诱发的多形性室性心动过速的病例，该患者的肾功能不全可能延长了心律失常的持续时间。在使用喷他脒期间应进行仔细的心电图监测，尤其是在肾功能不全的患者中。医生应意识到，这种多形性室性心动过速可在喷他脒的推荐剂量范围内发生。需要更多数据来确定肾功能不全、血浆水平与喷他脒心脏毒性之间的关系。
