Milasin J, Mićić S
Institute of Biology and Human Genetics, School of Stomatology, University of Belgrade, Yugoslavia.
Urol Int. 1992;48(3):258-60. doi: 10.1159/000282346.
A cytogenetically detectable form of gene amplification, presumably oncogene amplification, double minute chromosomes, has been found in 11 out of 45 specimens (24%) of moderately and poorly differentiated, deeply infiltrating transitional cell carcinoma of the bladder and ureter. None of the 75 low-grade low-stage tumors contained this karyotypic anomaly. It is obvious that double minutes are not a rare and sporadic phenomenon in this type of tumors; additionally there is strong evidence that they are involved in tumor progression, i.e. they are associated with tumor aggressiveness and unfavorable prognosis.
在45例中分化和低分化、浸润性强的膀胱及输尿管移行细胞癌标本中，有11例（24%）发现了一种细胞遗传学可检测到的基因扩增形式，推测为癌基因扩增，即双微体染色体。75例低级别低分期肿瘤中均未出现这种核型异常。显然，双微体在这类肿瘤中并非罕见的偶发现象；此外，有强有力的证据表明它们与肿瘤进展有关，即与肿瘤侵袭性和不良预后相关。
