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糖尿病严重程度指数的开发与验证:一种用于预测医疗资源使用和成本的风险调整工具。

Development and validation of a diabetes mellitus severity index: a risk-adjustment tool for predicting health care resource use and costs.

作者信息

Joish Vijay N, Malone Daniel C, Wendel Christopher, Draugalis Jolaine R, Mohler M Jane

机构信息

Department of Pharmacotherapy, College of Pharmacy, Pharmacotherapy Outcomes Research Center, University of Utah, Salt Lake City, 84108, USA.

出版信息

Pharmacotherapy. 2005 May;25(5):676-84. doi: 10.1592/phco.25.5.676.63594.

DOI:10.1592/phco.25.5.676.63594
PMID:15899729
Abstract

STUDY OBJECTIVE

To develop and validate a diabetes mellitus-specific risk-adjustment tool--the diabetes severity index (DSI)--to assist in predicting health care costs and resources within populations of patients with diabetes.

DESIGN

Retrospective analysis of clinical and resource use for patients with a diagnosis of diabetes mellitus. Model estimation was conducted with half the sample, and validation analysis was conducted with the other half.

SETTING

Southern Arizona Veterans Affairs Health Care System.

PATIENTS

Seven hundred thirty-four patients with diabetes (710 men, 24 women; mean age 66 yrs).

MEASUREMENTS AND MAIN RESULTS

Clinical measures of diabetes severity (known as the DSI) were used to predict three health care resource outcomes: risk of hospitalization, and total and ambulatory health care costs. Validity of the DSI was assessed by comparing the DSI with the revised chronic disease score (CDS). The DSI weights ranged from -471.5-3081.2 for total health care costs, from -304.3-1582.1 for outpatient costs, and -0.19-0.93 for risk of hospitalization. The DSI explained 6-8% of the variance in total and ambulatory costs and performed significantly (p<0.05) better than demographics alone, but was similar to the CDS. When the DSI was used with the CDS, up to 8% of variability in costs and use were explained.

CONCLUSION

The DSI was developed to stratify veterans with diabetes according to diabetes severity and comorbidity. Since additional variance in medical care costs were explained by combining the DSI and CDS, the two indexes may explain different dimensions of a patient's severity of diabetes. However, the utility of such an index based on clinical measures to predict short-term use may be limited due to low yet significant variability explained in the outcomes.

摘要

研究目的

开发并验证一种糖尿病特异性风险调整工具——糖尿病严重程度指数(DSI),以协助预测糖尿病患者群体的医疗保健成本和资源。

设计

对诊断为糖尿病的患者的临床和资源使用情况进行回顾性分析。模型估计使用一半样本进行,验证分析使用另一半样本进行。

设置

亚利桑那州南部退伍军人事务医疗保健系统。

患者

734例糖尿病患者(710例男性,24例女性;平均年龄66岁)。

测量和主要结果

使用糖尿病严重程度的临床测量指标(即DSI)来预测三种医疗保健资源结果:住院风险、总体和门诊医疗保健成本。通过将DSI与修订后的慢性病评分(CDS)进行比较来评估DSI的有效性。DSI权重在总体医疗保健成本方面为-471.5至3081.2,门诊成本方面为-304.3至1582.1,住院风险方面为-0.19至0.93。DSI解释了总体和门诊成本中6%-8%的方差,并且显著(p<0.05)优于仅使用人口统计学因素,但与CDS相似。当DSI与CDS一起使用时,成本和使用情况中高达8%的变异性得到了解释。

结论

DSI旨在根据糖尿病严重程度和合并症对糖尿病退伍军人进行分层。由于将DSI和CDS结合起来可以解释医疗保健成本中的额外方差,这两个指数可能解释了患者糖尿病严重程度的不同维度。然而,由于结果中解释的变异性较低但显著,基于临床测量指标的此类指数预测短期使用的效用可能有限。

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