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一项针对有糖尿病和医疗补助覆盖患者的初级保健嵌入的临床药师主导干预措施的效果研究。

An Effectiveness Study of a Primary Care-embedded Clinical Pharmacist-Led Intervention Among Patients With Diabetes and Medicaid Coverage.

机构信息

Division of General Internal Medicine and Health Services Research, Department of Medicine, University of California, Los Angeles, CA, USA.

Center for Health Advancement, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA.

出版信息

J Pharm Pract. 2024 Feb;37(1):66-73. doi: 10.1177/08971900221125008. Epub 2022 Sep 2.

Abstract

Examine the impact of a primary care-embedded clinical pharmacist-led intervention (UCMyRx) on hemoglobin A1C and blood pressure control, relative to usual care, among patients with Type 2 diabetes (TD2) and Medicaid, in a large healthcare system. We used data extracted from the Electronic Health Records system and a Difference-In-Differences study design with a 2:1 propensity-matched comparison group to evaluate the impact of UCMyRx on HbA1c and systolic blood pressure among patients with TD2 and Medicaid, relative to usual care. Having at least one UCMyRx clinical pharmacist visit was associated with a significant reduction in HbA1c; (-.27%, -value= .03) but no impact on SBP. We do not find differential UCMyRx effects on HbA1c or SBP among the subpopulations with baseline HbA1C ≥9% or SBP ≥150 mmHg, respectively. In Charlson Comorbidity Index (CCI)-stratified analyses we found stronger UCMyRx effects on HbA1C (-.47%, -value< .02) among the CCI tercile with the lowest comorbidity score (CC1 ≤ 5). Significant UCMyRx effects are only observed among the subpopulation of Medicaid beneficiaries without Medicare (-.35%, -value= .02). The UCMyRx intervention is a useful strategy for improving HbA1c control among patients with TD2 and Medicaid.

摘要

考察在大型医疗体系中,相较于常规护理,初级保健嵌入的临床药师主导的干预措施(UCMyRx)对 2 型糖尿病(TD2)和医疗补助患者的血红蛋白 A1C 和血压控制的影响。我们使用从电子健康记录系统中提取的数据,并采用差分法(Difference-In-Differences)研究设计和 2:1 倾向匹配对照组,评估 UCMyRx 对 TD2 和医疗补助患者的 HbA1c 和收缩压的影响,相较于常规护理。至少有一次 UCMyRx 临床药师访问与 HbA1c 的显著降低相关;(-.27%,-值=.03),但对 SBP 没有影响。我们没有发现 UCMyRx 在基线 HbA1C≥9%或 SBP≥150mmHg 的亚组中对 HbA1C 或 SBP 有差异影响。在 Charlson 合并症指数(CCI)分层分析中,我们发现 UCMyRx 在 CCI 最低(CC1≤5)的 tertile 中对 HbA1C 的影响更强(-.47%,-值<.02)。仅在没有医疗保险的医疗补助受益人群中观察到 UCMyRx 的显著效果(-.35%,-值=.02)。UCMyRx 干预是改善 TD2 和医疗补助患者 HbA1C 控制的有效策略。

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