Arushanian E B, Tolpyshev B A
Ann Ist Super Sanita. 1978;14(1):35-42.
The effects of 5-hydroxytryptophan (5-HTP) and p-chlorophenylalanine (PCPA) on amphetamine-induced stereotyped behaviour (ASB) and on the behavioural and EEG effects of caudate nucleus stimulation have been studied in the cat. After a pretreatment with 5-HTP (10--30 mg/kg) the threshold dose of amphetamine to induce ASB remained the same, but its pattern assumed a more organized character with reduced amplitude of stereotyped movements. On the contrary, after PCPA (200 mg/kg) a disorganized pattern of ASB was observed. 5-HTP increased and PCPA decreased the threshold of the arrest reaction induced by low frequency stimulation of ventro-lateral parts of the head of caudate nucleus. 5-HTP and PCPA also influenced in the opposite direction caudate-induced spindle waves in the neocortex. The effects of amphetamine on behavioural and EEG pattern of arrest reaction due to stimulation of the caudate nucleus were antagonized by 5-HTP and potentiated by PCPA. It is supposed that serotonergic mechanisms present in the ventro-lateral regions of the caudate nucleus can modulate stereotyped behaviour triggered by amphetamine.
在猫身上研究了5-羟色氨酸（5-HTP）和对氯苯丙氨酸（PCPA）对苯丙胺诱导的刻板行为（ASB）以及对尾状核刺激的行为和脑电图效应的影响。用5-HTP（10-30mg/kg）预处理后，诱导ASB的苯丙胺阈值剂量保持不变，但其模式呈现出更有组织的特征，刻板运动的幅度减小。相反，在给予PCPA（200mg/kg）后，观察到ASB的模式紊乱。5-HTP提高而PCPA降低了低频刺激尾状核头部腹外侧部分所诱导的停止反应阈值。5-HTP和PCPA还对尾状核诱导的新皮质纺锤波产生相反方向的影响。5-HTP拮抗了苯丙胺对尾状核刺激所致停止反应的行为和脑电图模式的影响，而PCPA则增强了这种影响。据推测，尾状核腹外侧区域存在的5-羟色胺能机制可调节由苯丙胺引发的刻板行为。
