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[可拉唑对尾状核功能活性的影响]

[Effect of corazole on the functional activity of the caudate nucleus].

作者信息

Avakian R M, Dutov A A, Tolpyshev B A

出版信息

Farmakol Toksikol. 1976 Nov-Dec;39(6):647-51.

PMID:1035858
Abstract

In chronic experiments with freely moving cats the action of diverse metrazol doses on the d,1-amphetamine-induced stereotype behaviour and the arrest reaction following low frequency stimulation of the caudate nucleus was studied. After injections of metrazol (20--30 mg/kg, i.c.) myoclonic seizure jerks and decreased locomotion occurred. This state was accompanied by depression of the stereotype behaviour and lowered arrest reaction threshold. It is suggested that some behavioural and the EEG metrazol-induced changes may come as a result of the caudate nucleus activation.

摘要

在对自由活动的猫进行的慢性实验中,研究了不同剂量的戊四氮对d,l-苯丙胺引起的刻板行为以及尾状核低频刺激后的制止反应的作用。注射戊四氮(20 - 30毫克/千克,腹腔注射)后,出现肌阵挛性惊厥抽搐和运动减少。这种状态伴随着刻板行为的抑制和制止反应阈值的降低。有人认为,戊四氮引起的一些行为和脑电图变化可能是尾状核激活的结果。

相似文献

1
[Effect of corazole on the functional activity of the caudate nucleus].[可拉唑对尾状核功能活性的影响]
Farmakol Toksikol. 1976 Nov-Dec;39(6):647-51.
2
The role of serotonergic mechanisms on amphetamine-induced stereotyped behaviour.血清素能机制在苯丙胺诱导的刻板行为中的作用。
Ann Ist Super Sanita. 1978;14(1):35-42.
3
[The effect of caudate nucleus stimulation on phenamine stereotypy in cats].[尾状核刺激对猫苯丙胺刻板行为的影响]
Zh Vyssh Nerv Deiat Im I P Pavlova. 1975 Jan-Feb;25(1):171-8.
4
[Effect of phenamine and caffeine on the behavioral changes occurring after the cessation of caudate nucleus electric stimulation in cats].[苯丙胺和咖啡因对猫尾状核电刺激停止后出现的行为变化的影响]
Biull Eksp Biol Med. 1979 Dec;88(12):685-8.
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[Effect of clozapine on the behavioral and electrographic indices of the arrest function of the caudate nucleus in cats].[氯氮平对猫尾状核抑制功能的行为学和脑电图指标的影响]
Biull Eksp Biol Med. 1978 May;85(5):541-4.
6
[Change in phenamine stereotypy in cats after the electrical stimulation of the caudate nucleus].[猫尾状核电刺激后苯丙胺刻板行为的变化]
Biull Eksp Biol Med. 1979 Jun;87(6):518-21.
7
[Effect of large doses of phenamine after previous administration of 5-hydroxytryptophan and para-chlorophenylalanine on the spontaneous behavior of cats and the effects induced by caudate nucleus stimulation].[预先给予5-羟色氨酸和对氯苯丙氨酸后大剂量苯丙胺对猫自发行为及尾状核刺激所诱导效应的影响]
Farmakol Toksikol. 1979 Mar-Apr;42(2):106-12.
8
[Different role of various regions of the caudate nucleus in phenamine-induced stereotyped behavior in cats].[尾状核各区域在苯丙胺诱导的猫刻板行为中的不同作用]
Zh Vyssh Nerv Deiat Im I P Pavlova. 1982;32(5):939-46.
9
Amphetamine stereotypy in cats and neurotransmitter interactions in the caudate nucleus. III. Effects of intracaudate injections of quipazine, cyproheptadine and electrical stimulation of the raphe dorsal nucleus.猫的苯丙胺刻板行为与尾状核中的神经递质相互作用。III. 尾状核内注射喹哌嗪、赛庚啶及中缝背核电刺激的影响
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10
Amphetamine stereotypy in cats and neurotransmitter interactions in the caudate nucleus. I. Effects of intracaudate injections of haloperidol, GABA and bicuculline.猫的苯丙胺刻板行为与尾状核中的神经递质相互作用。I. 尾状核内注射氟哌啶醇、γ-氨基丁酸和荷包牡丹碱的作用。
Acta Physiol Pharmacol Bulg. 1989;15(1):54-62.