杂双金属化二烯的串联Stille/Suzuki-Miyaura偶联反应。多烯体系的快速一锅法组装。
Tandem Stille/Suzuki-Miyaura coupling of a hetero-bis-metalated diene. Rapid, one-pot assembly of polyene systems.
作者信息
Coleman Robert S, Walczak Matthew C
机构信息
Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA.
出版信息
Org Lett. 2005 May 26;7(11):2289-91. doi: 10.1021/ol050768u.
[structure: see text]. The synthesis of a hetero-bis-metallo 1,3-butadiene is reported, and its use as an orthogonal Stille and Suzuki-Miyaura coupling partner is detailed. The tin/boron diene participated successfully in a one-pot, sequential Stille and Suzuki-Miyaura coupling protocol, and its utility was demonstrated in the two-step construction of the pentaene side chain of the Fusarium metabolite lucilactaene.
[结构：见正文]。报道了一种杂双金属1,3 - 丁二烯的合成，并详细介绍了其作为正交的施蒂勒（Stille）和铃木 - 宫浦（Suzuki - Miyaura）偶联伙伴的用途。锡/硼二烯成功参与了一锅法顺序施蒂勒和铃木 - 宫浦偶联反应，并且在镰刀菌代谢产物鲁西拉烯（lucilactaene）的戊烯侧链的两步构建中证明了其效用。
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