信使核糖核酸3'端加工与转录终止之间的联系。

Connections between mRNA 3' end processing and transcription termination.

作者信息

Buratowski Stephen

机构信息

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

出版信息

Curr Opin Cell Biol. 2005 Jun;17(3):257-61. doi: 10.1016/j.ceb.2005.04.003.

DOI:10.1016/j.ceb.2005.04.003

PMID:15901494

Abstract

Discoveries within the last few years have revealed that the multiple steps in gene expression are remarkably integrated. There have recently been several advances in deciphering how mRNA 3' end processing is linked with transcription elongation and termination. It has been known for quite a long time that transcription termination is somehow intertwined with polyadenylation, but it is still unclear exactly how these two processes influence each other. Some recent reports are shedding light on these connections.

摘要

过去几年的发现表明，基因表达的多个步骤紧密相连。最近在解读信使核糖核酸（mRNA）3' 末端加工如何与转录延伸和终止相联系方面取得了一些进展。人们早就知道转录终止在某种程度上与聚腺苷酸化相互交织，但这两个过程究竟如何相互影响仍不清楚。最近的一些报告正在揭示这些联系。