Kim Mi Kyung, Kwak Inho, Ki Moran, Fang Jinu, Kim Hyun Ja, Choi Bo Youl
Department of Preventive Medicine, Hanyang University, Seoul, Korea.
J Adolesc Health. 2005 Jun;36(6):501-7. doi: 10.1016/j.jadohealth.2005.01.014.
To follow offspring of emigrants from Korea to China to assess the effects of obesity and urbanization/westernization on atherogenic risk profiles. Obesity and serum lipid levels during adolescence are associated with risk for atherosclerotic diseases during adulthood, but the effect of obesity on serum lipid levels in relatively lean populations is unclear, particularly among adolescents.
The correlation of anthropometric measures with serum lipids was assessed in 2345 adolescents aged 16 to 18 years (four study groups: Korean-Chinese, n = 701; Korean-Rural, n = 671; Korean-Urban, n = 523; and Han-Chinese, n = 450).
Korean adolescents had higher average total cholesterol (TC) levels (146 mg/dl and 156 mg/dl for boys and girls, respectively) compared with Chinese adolescents (127 mg/dl and 143 mg/dl in China, respectively). The racial difference in atherogenic lipids (TC, low-density lipoprotein cholesterol [LDL-C], or their ratio to high-density lipoprotein cholesterol [HDL-C]) between Korean-Chinese and Han-Chinese was not found, but the urbanization difference among Korean adolescents (Korean-Chinese, Korean-Rural, and Korean-Urban) was obvious. The correlations of serum lipid levels with obesity indices were significant in TC, LDL-C, TC/HDL-C, LDL-C/HDL-C, and triglyceride (TG) among boys (p < .001) and in HDL-C, TC/HDL-C, LDL-C/HDL-C, and TG among girls (p < .05), but not strongly correlated (Pearson r < .2).
Significantly higher levels of TC and LDL-C (approximately 20 mg/dl) in Korean adolescents compared with Chinese adolescents were not owing to obesity or any racial difference. These findings underscore the importance of health promotion strategies including changes of lifestyle during childhood and adolescence.
追踪从韩国移民到中国的人群的后代，以评估肥胖以及城市化/西方化对动脉粥样硬化风险状况的影响。青少年时期的肥胖和血脂水平与成年期动脉粥样硬化疾病的风险相关，但肥胖对相对瘦人群血脂水平的影响尚不清楚，尤其是在青少年中。
对2345名16至18岁的青少年（四个研究组：朝鲜族中国人，n = 701；朝鲜族农村，n = 671；朝鲜族城市，n = 523；汉族，n = 450）的人体测量指标与血脂之间的相关性进行了评估。
与中国青少年（中国男孩为127mg/dl，女孩为143mg/dl）相比，韩国青少年的平均总胆固醇（TC）水平更高（男孩和女孩分别为146mg/dl和156mg/dl）。未发现朝鲜族中国人和汉族之间在致动脉粥样硬化脂质（TC、低密度脂蛋白胆固醇[LDL-C]或它们与高密度脂蛋白胆固醇[HDL-C]的比值）方面存在种族差异，但韩国青少年（朝鲜族中国人、朝鲜族农村和朝鲜族城市）之间的城市化差异很明显。男孩中，血清脂质水平与肥胖指数在TC、LDL-C、TC/HDL-C、LDL-C/HDL-C和甘油三酯（TG）方面显著相关（p <.001），女孩中在HDL-C、TC/HDL-C、LDL-C/HDL-C和TG方面显著相关（p <.05），但相关性不强（Pearson r <.2）。
与中国青少年相比，韩国青少年的TC和LDL-C水平显著更高（约20mg/dl），这并非由于肥胖或任何种族差异。这些发现强调了包括儿童期和青少年期生活方式改变在内的健康促进策略的重要性。
