Department of Endocrinology, Guangzhou Panyu Central Hospital, Guangzhou, Guangdong, China
Department of Endocrinology, Guangzhou Panyu Central Hospital, Guangzhou, Guangdong, China.
BMJ Open. 2023 Aug 31;13(8):e075311. doi: 10.1136/bmjopen-2023-075311.
Previous studies investigating the association between the serum triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio and the occurrence of sarcopenia in different populations have yielded inconsistent results. This study aimed to investigate the potential association between TG/HDL-C ratio and sarcopenia among elderly Chinese patients with diabetes.
A secondary data analysis.
This was a secondary analysis of data from the China Health and Retirement Longitudinal Study.
In this study, 752 elderly individuals with diabetes were included after excluding individuals aged <60 years old, those with missing data for the assessment of sarcopenia and missing measurements for plasma glucose or glycated haemoglobin.
The primary information included TG/HDL-C ratio, muscle strength, physical performance, muscle mass and covariables. The association between TG/HDL-C ratio and sarcopenia was assessed using ordinal logistic regression and linear regression analysis.
On multivariate ordinal logistic regression, among male patients, compared with those with the lowest quartile of TG/HDL-C ratio (≤1.41), those with the highest quartile (>4.71) had a significantly lower risk of more severe sarcopenia (OR 0.24, 95% CI 0.10 to 0.54). Similarly, among female patients, compared with those with the lowest quartile of TG/HDL-C ratio (≤2.07), those with the highest quartile (>5.61) had a significantly lower risk of more severe sarcopenia (OR 0.17, 95% CI 0.07 to 0.44). In multivariate linear regression, male patients with the highest quartile of TG/HDL-C ratio (β=0.36, 95% CI 0.20 to 0.51) had higher muscle mass than those with the lowest quartile. Similarly, female patients with the highest quartile of TG/HDL-C ratio (β=0.31, 95% CI 0.10 to 0.51) had higher muscle mass than those with the lowest quartile.
There was a negative association between TG/HDL-C ratio categorised by quartile and sarcopenia, which indicates that a higher TG/HDL-C ratio may be related to better muscle status.
先前研究调查了血清甘油三酯与高密度脂蛋白胆固醇（TG/HDL-C）比值与不同人群肌少症发生之间的关联，但结果并不一致。本研究旨在探讨 TG/HDL-C 比值与老年糖尿病患者肌少症之间的潜在关联。
二次数据分析。
这是对中国健康与退休纵向研究数据的二次分析。
在排除了年龄<60 岁、肌少症评估数据缺失以及血糖或糖化血红蛋白测量值缺失的个体后，本研究纳入了 752 名老年糖尿病患者。
主要信息包括 TG/HDL-C 比值、肌肉力量、身体表现、肌肉质量和协变量。采用有序逻辑回归和线性回归分析评估 TG/HDL-C 比值与肌少症之间的关系。
在多变量有序逻辑回归中，与 TG/HDL-C 比值最低四分位数（≤1.41）的男性患者相比，TG/HDL-C 比值最高四分位数（>4.71）的患者发生更严重肌少症的风险显著降低（比值比 0.24，95%置信区间 0.10 至 0.54）。同样，与 TG/HDL-C 比值最低四分位数（≤2.07）的女性患者相比，TG/HDL-C 比值最高四分位数（>5.61）的患者发生更严重肌少症的风险显著降低（比值比 0.17，95%置信区间 0.07 至 0.44）。在多变量线性回归中，TG/HDL-C 比值最高四分位数的男性患者（β=0.36，95%置信区间 0.20 至 0.51）的肌肉质量高于最低四分位数患者。同样，TG/HDL-C 比值最高四分位数的女性患者（β=0.31，95%置信区间 0.10 至 0.51）的肌肉质量高于最低四分位数患者。
按四分位数分类的 TG/HDL-C 比值与肌少症呈负相关，这表明较高的 TG/HDL-C 比值可能与更好的肌肉状态有关。
