Vyazovskiy Vladyslav V, Ruijgrok Guido, Deboer Tom, Tobler Irene
Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Cereb Cortex. 2006 Mar;16(3):328-36. doi: 10.1093/cercor/bhi110. Epub 2005 May 18.
Regional aspects of sleep homeostasis were investigated in mice provided with a running wheel for several weeks. Electroencephalogram (EEG) spectra of the primary motor (frontal) and somatosensory cortex (parietal) were recorded for three consecutive days. On a single day (day 2) the wheel was locked to prevent running. Wheel running correlated negatively with the frontal-parietal ratio of slow-wave activity (EEG power between 0.75 and 4.0 Hz) in the first 2 h after sleep onset (r = -0.60; P < 0.01). On day 2 frontal EEG power (2.25-8.0 Hz) in non-rapid eye movement sleep exceeded the level of the previous day, indicating that the diverse behaviors replacing wheel-running elicited more pronounced regional EEG differences. The frontal-parietal power ratio of the lower frequency bin (0.75-1.0 Hz) in the first 2 h of sleep after dark onset correlated positively with the duration of the preceding waking (r = 0.64; P < 0.001), whereas the power ratio in the remaining frequencies of the delta band (1.25-4.0 Hz) was unrelated to waking. The data suggest that in mice EEG power in the lower frequency, corresponding to the slow oscillations described in cats and humans, is related to local sleep homeostasis.
在为小鼠提供跑步轮数周后，对睡眠稳态的区域特征进行了研究。连续三天记录初级运动（额叶）和体感皮层（顶叶）的脑电图（EEG）频谱。在某一天（第2天），将跑步轮锁定以防止小鼠跑动。在睡眠开始后的前2小时内，跑步与慢波活动的额叶 - 顶叶比率（EEG功率在0.75至4.0 Hz之间）呈负相关（r = -0.60；P < 0.01）。在第2天，非快速眼动睡眠中的额叶EEG功率（2.25 - 8.0 Hz）超过了前一天的水平，这表明替代跑步的各种行为引发了更明显的区域EEG差异。黑暗开始后睡眠的前2小时内，低频段（0.75 - 1.0 Hz）的额叶 - 顶叶功率比与之前清醒的持续时间呈正相关（r = 0.64；P < 0.001），而δ波段其余频率（1.25 - 4.0 Hz）的功率比与清醒无关。数据表明，在小鼠中，对应于猫和人类中描述的慢振荡的低频EEG功率与局部睡眠稳态有关。
